Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
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EASL-EORTC clinical practice guidelines : management of hepatocellular carcinoma
Peter R. Galle,Alejandro Forner,Josep M. Llovet,Vincenzo Mazzaferro,Fabio Piscaglia,Jean-Luc Raoul,Peter Schirmacher,Valérie Vilgrain +7 more
TL;DR: The following Clinical Practice Guidelines will give up-to-date advice for the clinical management of patients with hepatocellular carcinoma, as well as providing an in-depth review of all the relevant data leading to the conclusions herein.
Journal ArticleDOI
Epidemiology of Viral Hepatitis and Hepatocellular Carcinoma
TL;DR: This review summarizes the risk factors for HCC among HBV- or HCV-infected individuals, based on findings from epidemiologic studies and meta-analyses, as well as determinants of patient outcome and the HCC disease burden, globally and in the United States.
EASL-EORTC Clinical Practice Guidelines: Management of hepatocellular carcinoma European Association for the Study of the Liver ⇑ , European Organisation for Research and Treatment of Cancer
Josep M. Llovet,Michel Ducreux,Riccardo Lencioni,Adrian M. Di Bisceglie,Jean-Francois J. DuFour,Tim F. Greten,Eric Raymond,Tania Roskams,Vincenzo Mazzaferro,Jordi Bruix,Massimo Colombo,Andrew X. Zhu +11 more
TL;DR: The purpose of this document is to assist physicians, patients, health-care providers, and health-policy makers from Europe and worldwide in the decision-making process according to evidencebased data.
Journal ArticleDOI
EASL Clinical Practice Guidelines: Management of chronic hepatitis B
C.P.G.P.P. Marcellin,G.M. Dusheiko,Fabien Zoulim,Rafael Esteban,Stephanos J. Hadziyannis,Pietro Lampertico,M.P. Manns,Daniel Shouval,Cihan Yurdaydin,R.A. Craxi,Xavier Forns,Darius Moradpour,Jean-Michel Pawlotsky,Jörg Petersen,H.W.F. Easl +14 more
TL;DR: The objective of these EASL Clinical Practice Guidelines is to update recommendations for the optimal management of chronic hepatitis B (CHB) and the CPGs do not focus on prevention and vaccination.
Journal ArticleDOI
Hepatitis B virus infection
TL;DR: Developing new therapies that can improve HBsAg clearance and virological cure is warranted because long-term antiviral treatment can reverse cirrhosis and reduce hepatocellular carcinoma.
References
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Journal ArticleDOI
Hepatitis B e antigen-negative chronic hepatitis B: natural history and treatment.
TL;DR: The long-term resistance profile of adefovir is significantly better than that of lamivudine (LMV), whereas data for entecavir currently are limited to 2 years, with resistance developing in LMV-resistant but not in treatment-naïve patients.
Journal ArticleDOI
Natural history of chronic HBV carriers in Northern Italy: Morbidity and mortality after 30 years
Mauro Manno,Calogero Cammà,Filippo Schepis,Fabio Bassi,Roberta Gelmini,F. Giannini,Francesca Miselli,Antonella Grottola,Ilva Ferretti,Chiara Vecchi,Marisa De Palma,Erica Villa +11 more
TL;DR: Over a 30-year period, chronic HBV carrier blood donors from Northern Italy did not develop clinically significant liver disease, hepatocellular cancer, or other liver-related morbidity or mortality at a higher rate than uninfected controls.
Journal ArticleDOI
Hepatitis B Virus Genotypes in Alaska Native People with Hepatocellular Carcinoma: Preponderance of Genotype F
Stephen Livingston,Josephine Simonetti,Brian J. McMahon,Brian J. McMahon,Lisa R. Bulkow,Kathy J. Hurlburt,Chriss Homan,Mary Snowball,Henry H. Cagle,James L. Williams,Vladimir Chulanov +10 more
TL;DR: A significant association between genotype F and the development of HCC among Alaska Native people with chronic HBV infection is found but nosignificant association between HCC and basal core promoter or precore mutations in genotypes F is found.
Journal ArticleDOI
Natural course and response to interferon of chronic hepatitis B accompanied by antibody to hepatitis B e antigen.
Maurizia Rossana Brunetto,Filippo Oliveri,Giuseppe Rocca,Domenico Criscuolo,E. Chiaberge,M Capalbo,Ezio David,Giorgio Verme,Ferruccio Bonino +8 more
TL;DR: The results suggest that chronic hepatitis B with anti‐HBe in serum differs from chronic hepatitis with HBeAg in both natural history and response to interferon, witheculiar features are the frequency of spontaneous remissions and a high frequency of reactivation after a response to Interferon.
Journal ArticleDOI
HBsAg seroclearance in chronic hepatitis B in the Chinese: virological, histological, and clinical aspects
Man-Fung Yuen,Danny Ka-Ho Wong,Erwin Sablon,Eric Tse,Irene Oi-Lin Ng,He-Jun Yuan,Chung-Wah Siu,Tamara J. Sander,Eric J. Bourne,Jeff G. Hall,Lynn D. Condreay,Ching-Lung Lai +11 more
TL;DR: Patients with HBsAg seroclearance had favorable biochemical, virological, and histological parameters, and HCC could still develop, particularly in patients with cirrhosis who had HBs Ag serocLearance at an older age.