Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
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Journal ArticleDOI
Hepatitis B therapy in children.
TL;DR: Watchful waiting of children is an option since current therapies are only 30% effective at best, although the long-term impact of therapy in childhood on rates of cirrhosis and hepatocellular carcinoma remains unknown.
Journal ArticleDOI
Point-of-Care Tests for Hepatitis B: An Overview.
Yinzong Xiao,Yinzong Xiao,Yinzong Xiao,Alexander J. Thompson,Alexander J. Thompson,Jessica Howell +5 more
TL;DR: This review presents currently available point-of-care tests for hepatitis B and their roles in the care cascade, reviewing evidence for testing performance, utility, acceptability, costs and cost-effectiveness when integrated into hepatitis B diagnosis and monitoring programs.
Journal ArticleDOI
Soluble programmed death‐1 is a useful indicator for inflammatory and fibrosis severity in chronic hepatitis B
TL;DR: The association between sPD‐1 and disease progression of CHB suggests that s PD‐1 could serve as a new indicator in assessing liver fibrosis, and may further aid in determining the initiation of antiviral treatment in patients with normal ALT levels.
Journal ArticleDOI
Clinical features of acute hepatitis E super-infections on chronic hepatitis B.
Chong Chen,Shuye Zhang,Dan-Dan Zhang,Xinyan Li,Yuling Zhang,Wei-Xia Li,Jingjing Yan,Min Wang,Jing-Na Xun,Chuan Lu,Yun Ling,Yu-Xian Huang,Liang Chen +12 more
TL;DR: CHB-related cirrhosis and intermediate HBV DNA level were associated with severe disease in superinfected patients, and successful antiviral treatment might counter this outcome.
Journal ArticleDOI
Precore/Core promoter variants to predict significant fibrosis in both HBeAg positive and negative chronic hepatitis B
M. Lapalus,Cédric Laouénan,Ana-Carolina Cardoso,E. Estrabaud,Roberto J. Carvalho-Filho,Q. Zhang,Olivier Lada,Kevin Appourchaux,Feryel Mouri,Nathalie Boyer,Pierre Bedossa,Tarik Asselah,Michelle Martinot-Peignoux,Patrick Marcellin +13 more
TL;DR: The objective was to investigate the relationship between fibrosis, host and viral factors to identify non‐invasive markers of significant fibrosis in a large cohort of unselected, well‐characterized, treatment‐naïve CHB patients.
References
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Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
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Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
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The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
TL;DR: HBV and HCV infections account for the majority of cirrhosis and primary liver cancer throughout most of the world, highlighting the need for programs to prevent new infections and provide medical management and treatment for those already infected.
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Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
TL;DR: Further studies are needed to investigate other viral factors (eg, HBV genotype/mutant, occult HBV, HIV coinfection) and preventable or treatable comorbidities ( eg, obesity, diabetes) in the HCC risk in cirrhosis.