Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
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Journal ArticleDOI
Evaluation of storing hepatitis B vaccine outside the cold chain in the Solomon Islands: Identifying opportunities and barriers to implementation
TL;DR: Storing HepB OCC can increase HepB-BD coverage in countries with insufficient cold chain capacity or numerous home births and high vaccine wastage and unreliable vaccine supply must be addressed for successful implementation.
OtherDOI
Epidemiology of Hepatocellular Carcinoma
TL;DR: The role of diet except for alcohol drinking and aflatoxin contamination in the etiology of HCC in human populations is largely unknown as mentioned in this paper, however, the causal link is still unclear.
Journal ArticleDOI
Natural killer cells in hepatitis B virus infection.
TL;DR: The roles of natural killer cells in hepatitis B virus infection are reviewed, introducing novel therapeutic strategies for controlling hepatitis Birus infection via the modulation of natural Killer cells.
Journal ArticleDOI
Serum alanine aminotransferase level and liver‐related mortality in patients with chronic hepatitis B: A large national cohort study
Jae-Jun Shim,Jung-Wook Kim,Chi Hyuk Oh,Ye-Rin Lee,Ji Sung Lee,So-Youn Park,Byung-Ho Kim,In-Hwan Oh +7 more
TL;DR: The serum alanine aminotransferase level has been used to identify at‐risk patients with chronic hepatitis B who need antiviral therapy, but the level associated with increased liver‐related mortality requiring active treatment is still unclear.
Journal ArticleDOI
Remaining hepatocellular carcinoma risk in chronic hepatitis B patients receiving entecavir/tenofovir in South Korea
TL;DR: The incidence rate of hepatocellular carcinoma in chronic hepatitis B patients treated with entecavir or tenofovir in South Korea is identified and predictors of HCC development in these patients are identified.
References
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Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
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Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
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The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
TL;DR: HBV and HCV infections account for the majority of cirrhosis and primary liver cancer throughout most of the world, highlighting the need for programs to prevent new infections and provide medical management and treatment for those already infected.
Journal ArticleDOI
Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
TL;DR: Further studies are needed to investigate other viral factors (eg, HBV genotype/mutant, occult HBV, HIV coinfection) and preventable or treatable comorbidities ( eg, obesity, diabetes) in the HCC risk in cirrhosis.