Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
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Screening for Hepatitis B Virus Infection in Nonpregnant Adolescents and Adults: Systematic Review to Update the 2004 U.S. Preventive Services Task Force Recommendation
TL;DR: This data indicates that high-dose intra-dermal generic and disease-specific health outcomes of hepatitis B virus Vaccine in previous vaccination patients with chronic hepatitis C and experienced patients coinfected with HIV-1 and Carreno V are more likely to be harmful than beneficial.
Journal ArticleDOI
Deep sequencing analysis of quasispecies in the HBV pre-S region and its association with hepatocellular carcinoma.
An-Ye Zhang,Ching-Lung Lai,Fung-Yu Huang,Wai-Kay Seto,James Fung,Danny Ka-Ho Wong,Man-Fung Yuen +6 more
TL;DR: Increased HBV quasispecies complexity and diversity in the pre-S region, probably reflecting enhanced virus–host interplay, was associated with disease progression from CHB to HCC.
Journal ArticleDOI
Methylation of the Glutathione-S-Transferase P1 Gene Promoter Is Associated with Oxidative Stress in Patients with Chronic Hepatitis B
TL;DR: It is demonstrated that GSTP1 hypermethylation was associated with DNMT1, DNMT3a overexpression and oxidative stress in patients with HBeAg-positive CHB, and no significant difference was found between GSTM3 methylation in Patients with CHB and HCs.
Journal ArticleDOI
Role of antiviral therapy in the natural history of hepatitis B virus-related chronic liver disease.
Francesco Paolo Russo,Kryssia I. Rodriguez-Castro,L. Scribano,Giorgia Gottardo,V. Vanin,Fabio Farinati +5 more
TL;DR: CHB infection cannot be completely eradicated, due to the persistence of covalently closed circular DNA in the nucleus of infected hepatocytes, which may explain HBV reactivation.
Journal ArticleDOI
Clinical, demographic and epidemiological characteristics of patients with hepatitis B followed at a university hospital in southeastern Brazil: predominance of HBeAg negative cases
Silvana Gama Florencio Chachá,Sandro da Costa Ferreira,Tarciana Vieira Costa,Luiz Carlos de Almeida Filho,Márcia Guimarães Villanova,Fernanda Fernandes Souza,Andreza Correa Teixeira,José Fernando de Castro Figueiredo,Sérgio Zucoloto,Leandra Naira Zambelli Ramalho,Afonso Dinis Costa Passos,Ana de Lourdes Candolo Martinelli +11 more
TL;DR: In this article, the clinical, demographic and epidemiological characteristics of patients chronically infected with hepatitis B virus (HBV) residing in the Ribeirao Preto region, southeastern Brazil were determined.
References
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Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
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Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
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The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
TL;DR: HBV and HCV infections account for the majority of cirrhosis and primary liver cancer throughout most of the world, highlighting the need for programs to prevent new infections and provide medical management and treatment for those already infected.
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Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
TL;DR: Further studies are needed to investigate other viral factors (eg, HBV genotype/mutant, occult HBV, HIV coinfection) and preventable or treatable comorbidities ( eg, obesity, diabetes) in the HCC risk in cirrhosis.