Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
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EASL-EORTC clinical practice guidelines: management of hepatocellular carcinoma
Journal ArticleDOI
Epidemiology of hepatocellular carcinoma: target population for surveillance and diagnosis.
TL;DR: This work discusses general trends pertaining to geographic region, age, gender, ethnicity, impact of surveillance on survival, mortality, and future trends.
Journal ArticleDOI
Chronic hepatitis B virus infection.
TL;DR: Non-invasive assessment of liver fibrosis is emerging as an important assessment modality and long-term nucleos(t)ide-analogue therapy is safe and well tolerated, achieves potent viral suppression, and reduces the incidence of liver-related complications.
Journal ArticleDOI
The evolving epidemiology of hepatocellular carcinoma: a global perspective
TL;DR: Changing lifestyle and environmental factors in western countries plus rising neonatal hepatitis B vaccination rates and decreasing exposure to dietary aflatoxins in developing countries are driving an evolution of the epidemiology of this cancer.
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Combination of Tenofovir Disoproxil Fumarate and Peginterferon α-2a Increases Loss of Hepatitis B Surface Antigen in Patients With Chronic Hepatitis B
Patrick Marcellin,Sang Hoon Ahn,Xiaoli Ma,Florin Alexandru Caruntu,Won Young Tak,Magdy Elkashab,Wan-Long Chuang,Seng Gee Lim,Fehmi Tabak,R. Mehta,Joerg Petersen,Graham R. Foster,Lillian Lou,Eduardo B. Martins,Phillip Dinh,Lanjia Lin,Amoreena Corsa,Prista Charuworn,G. Mani Subramanian,Hans Reiser,Hendrick W. Reesink,Scott Fung,Simone I. Strasser,Huy N. Trinh,Maria Buti,Giovanni Battista Gaeta,Aric J. Hui,George V. Papatheodoridis,Robert Flisiak,Henry Lik-Yuen Chan +29 more
TL;DR: A significantly greater proportion of patients received TDF plus peginterferon for 48 weeks had HBsAg loss than those receiving TDF or peginerferon alone.
References
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Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
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Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
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The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
TL;DR: HBV and HCV infections account for the majority of cirrhosis and primary liver cancer throughout most of the world, highlighting the need for programs to prevent new infections and provide medical management and treatment for those already infected.
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Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
TL;DR: Further studies are needed to investigate other viral factors (eg, HBV genotype/mutant, occult HBV, HIV coinfection) and preventable or treatable comorbidities ( eg, obesity, diabetes) in the HCC risk in cirrhosis.