Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
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Journal ArticleDOI
Características y evolución de la infección crónica por virus de la hepatitis B antígeno e negativo
Antonio Guardiola Arévalo,Rafael Gómez Rodríguez,Marta Romero Gutiérrez,Ana Zaida Gómez Moreno,Almudena García Vela,Raquel Sánchez Simón,César Gómez Hernando,Eva María Andrés Esteban +7 more
TL;DR: Entre los enfermos con infeccion cronica por VHB AgHBe-negativo predominan los portadores inactivos, y un progresivo descenso de ADN-VHB en los primeros anos tras el diagnostico istan poca morbimortalidad.
Journal ArticleDOI
Alveolar process changes associated with administration of nucleos(t)ide analogue (sofosbuvir) in rat model.
TL;DR: It has been concluded that sofosbuvir induced apparent alterations in the rats' alveolar bone and this effect was exaggerated in a longer period of drug administration.
Journal ArticleDOI
Predicting clinical outcomes in patients with HBsAg-positive chronic hepatitis
Myron John Tong,Myron John Tong,Thatcher Thi Huynh,Surachate Siripongsakun,Surachate Siripongsakun,Patrick Weijen Chang,Lori Terese Tong,Yen Phi Ha,Edward Mena,Matthew Frank Weissman +9 more
TL;DR: To prevent progression, serial measurements of these parameters during the chronic hepatitis stage will assist in identifying patients requiring antiviral therapy.
Journal ArticleDOI
Immune therapy for hepatitis B.
Sheikh Mohammad Fazle Akbar,Mamun Al-Mahtab,Md. Sakilur Islam Khan,Ruksana Raihan,Ananta Shrestha +4 more
TL;DR: There is a pressing need to develop new and innovative therapeutic approaches for chronic hepatitis B patients because impaired or distorted or diminished immune responses have been detected in most of these patients and immune therapy seems to be an alternate therapeutic approach.
Journal ArticleDOI
Current laboratory tests for diagnosis of hepatitis B virus infection.
Jong Han Lee,Hyon Suk Kim +1 more
TL;DR: In this paper, a review of current diagnostic efforts for hepatitis B virus infection and future HBV diagnosis perspectives is presented, where the authors reviewed and summarized current laboratory diagnosis related with HBV infection in clinical practice.
References
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Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
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Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
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The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
TL;DR: HBV and HCV infections account for the majority of cirrhosis and primary liver cancer throughout most of the world, highlighting the need for programs to prevent new infections and provide medical management and treatment for those already infected.
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Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
TL;DR: Further studies are needed to investigate other viral factors (eg, HBV genotype/mutant, occult HBV, HIV coinfection) and preventable or treatable comorbidities ( eg, obesity, diabetes) in the HCC risk in cirrhosis.