Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
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Hepatitis B Virus Epidemiology
TL;DR: The increased recognition of HBV infection as a leading cause of death globally has resulted in the development of new structures and policies at the international level; immediate attention to implementing these strategies is now required.
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The state of hepatitis B and C in Europe: report from the hepatitis B and C summit conference*
Angelos Hatzakis,Suzanne Wait,Jordi Bruix,Maria Buti,M. Carballo,M. Cavaleri,Massimo Colombo,Elisabeth Delarocque-Astagneau,G.M. Dusheiko,Gamal Esmat,Rafael Esteban,David J. Goldberg,Charles Gore,Anna S.F. Lok,Michael Manns,Patrick Marcellin,George V. Papatheodoridis,A. Peterle,Daniele Prati,N. Piorkowsky,Mario Rizzetto,F. Roudot-Thoraval,Vincent Soriano,Howard C. Thomas,Mark Thursz,Dominique Valla,P. Van Damme,Irene K. Veldhuijzen,H. Wedemeyer,Lucas Wiessing,A.R. Zanetti,H L A Janssen +31 more
TL;DR: For both HBV and HCV, screening of individuals who present a high risk of contracting the virus is critical given the asymptomatic, and thereby silent, nature of disease.
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New insight in the pathobiology of hepatitis B virus infection
Maura Dandri,Stephen Locarnini +1 more
TL;DR: Current knowledge of factors influencing the course of HBV infection is summarized, giving emphasis on the use of novel assays and quantitative serological and intrahepatic biomarkers as tools for predicting treatment response and disease progression.
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The hepatitis delta virus: Replication and pathogenesis.
Camille Sureau,Francesco Negro +1 more
TL;DR: Molecular aspects of HDV replication cycle are covered, including its interaction with the helper HBV and the pathogenesis of infection in humans.
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Strategies to control hepatitis B: Public policy, epidemiology, vaccine and drugs
TL;DR: Development of effective screening assays for surveillance, vaccines for prevention and antiviral drugs that significantly improve patient clinical outcomes and the provision of a framework for global action present a real opportunity to reduce the significant, social and economic burden of global hepatitis B.
References
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Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
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Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
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The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
TL;DR: HBV and HCV infections account for the majority of cirrhosis and primary liver cancer throughout most of the world, highlighting the need for programs to prevent new infections and provide medical management and treatment for those already infected.
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Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
TL;DR: Further studies are needed to investigate other viral factors (eg, HBV genotype/mutant, occult HBV, HIV coinfection) and preventable or treatable comorbidities ( eg, obesity, diabetes) in the HCC risk in cirrhosis.