Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
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Journal ArticleDOI
Challenges in Formulation and Implementation of Hepatitis B Elimination Programs.
Zaigham Abbas,Minaam Abbas +1 more
TL;DR: In this paper, the authors proposed to eliminate hepatitis B infection by screening pregnant women and starting antiviral therapy from the 28th week of pregnancy if hepatitis B virus (HBV) DNA ≥ 200,000 IU/mL or hepatitis B e-antigen (HBeAg) reactive.
DissertationDOI
Influência da infecção pregressa pelo vírus da hepatite B em portadores de hepatite C crônica: análise histológica
Journal ArticleDOI
Hepatitis B virus genotypes and subgenotypes and the natural history and epidemiology of hepatitis B.
Tania Reuter,Michele Soares Gomes-Gouvêa,Samira Chuffi,Ulisses Horst Duque,Jose Américo Carvalho,Waltesia Perini,Marcello Moro Queiroz,Ingrid Marques Segal,Raymundo Soares Azevedo,João Renato Rebello Pinho +9 more
TL;DR: In this paper, the authors characterized the demographic, epidemiological, laboratory, virological (HBe/anti-HBe status, viral load, genotypes, subgenotypes), and clinical aspects of 587 chronic hepatitis B carriers followed up at the hepatitis B Outpatient Clinic of the Infectious Diseases Service of the University of Espirito Santo (HUCAM/UFES).
Journal ArticleDOI
Hepatitis B virus (HBV) infection and hepatocarcinogenesis
TL;DR: The molecular mechanisms of virus-induced carcinogenesis, indirect and direct effects of the infection are discussed, and integration of HBV DNA in to the host DNA, activation of oncogenes and inactivation of tumor suppressor genes are of basic significance.
References
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Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
Journal ArticleDOI
Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
Journal ArticleDOI
Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
Journal ArticleDOI
The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
TL;DR: HBV and HCV infections account for the majority of cirrhosis and primary liver cancer throughout most of the world, highlighting the need for programs to prevent new infections and provide medical management and treatment for those already infected.
Journal ArticleDOI
Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
TL;DR: Further studies are needed to investigate other viral factors (eg, HBV genotype/mutant, occult HBV, HIV coinfection) and preventable or treatable comorbidities ( eg, obesity, diabetes) in the HCC risk in cirrhosis.