Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
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Validation of Hepatocellular Carcinoma Risk Prediction Models in Patients with Hepatitis B-Related Cirrhosis
TL;DR: In this paper , a Cox proportional hazards model was used to analyze the risk factors for hepatocellular carcinoma (HCC) in patients with chronic hepatitis B (CHB) undergoing antiviral therapy.
Microcystins and Liver Disease Mortality, Insights from an Ecological Study
TL;DR: Results may encourage water treatment plants in Brevard County and Manatee County, FL to monitor and manage cyanobacterial contamination in drinking water sources and positive social change can educate the federal and state governments to improve the surveillance of MCs.
Clinical studies on hepatitis B, C, and E virus infection
TL;DR: Clinical aspects of hepatitis B, C, and E virus infection are described, particularly on treatment-related topics, such as IP-10 as a response marker for interferon-based therapy, treatment of patients with chronic HCV infection with direct acting antiviral agents (DAAs), and an attempt to predict the effect of different treatment approaches on the size of the future HCV-viremic population andHCV-related disease burden.
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Vitamin D Receptor Fok I Polymorphism and Risk of Hepatocellular Carcinoma in HBV-Infected Patients
TL;DR: The results of the analysis suggest the “f” allele of Fok I polymorphism might be a risk factor for HCC in HBV-infected patients and it could be a predictive factor to screen HCC for patients infected with hepatitis B virus.
References
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Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
Journal ArticleDOI
Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
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The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
TL;DR: HBV and HCV infections account for the majority of cirrhosis and primary liver cancer throughout most of the world, highlighting the need for programs to prevent new infections and provide medical management and treatment for those already infected.
Journal ArticleDOI
Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
TL;DR: Further studies are needed to investigate other viral factors (eg, HBV genotype/mutant, occult HBV, HIV coinfection) and preventable or treatable comorbidities ( eg, obesity, diabetes) in the HCC risk in cirrhosis.