Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
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Then and now: the progress in hepatitis B treatment over the past 20 years.
TL;DR: This review will examine the antiviral drugs and the progresses that have been made with antiviral treatments in the field of CHB and the possibility of reducing the incidence of recurrent or new HCC in patients even after they have developed HCC.
Journal ArticleDOI
Nucleic acid polymers inhibit duck hepatitis B virus infection in vitro
TL;DR: The antiviral activity of NAPs against DHBV in vitro was strictly dependent on their amphipathic character, suggesting that NAP’s interact with amphipATHic target(s) that are important forDHBV entry and postentry mechanisms required for infection.
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Cost effectiveness of screening immigrants for hepatitis B.
TL;DR: Screening for hepatitis B surface antigen is not recommended for immigrants and the prevalence of chronic hepatitis B infection among the immigrants of North America ranges from 2 to 15%, among whom 40% develop advanced liver disease.
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Reduction of liver stiffness by antiviral therapy in chronic hepatitis B.
Keisuke Osakabe,Naohiro Ichino,Toru Nishikawa,Hiroko Sugiyama,Miho Kato,Shiho Kitahara,Senju Hashimoto,Naoto Kawabe,Masao Harata,Yoshifumi Nitta,Michihito Murao,Takuji Nakano,Hiroaki Shimazaki,Yuko Arima,Koji Suzuki,Kentaro Yoshioka +15 more
TL;DR: LS can be useful to assess the progression and regression of liver fibrosis stage noninvasively and the reduction by antiviral therapy was significantly correlated with the reduction of hyaluronic acid.
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High endemicity and low molecular diversity of hepatitis B virus infections in pregnant women in a rural district of North Cameroon.
Alexandra Ducancelle,Pierre Abgueguen,Jacques Birguel,Wael Y. Mansour,Adeline Pivert,Hélène Le Guillou-Guillemette,Jean-Jacques Sobnangou,Amélie Rameau,Jean-Marie Huraux,Françoise Lunel-Fabiani +9 more
TL;DR: The results confirm the high prevalence and low molecular diversity of HBV in Far Northern Cameroon; more than 20% of the infected women were highly viremic, suggesting a high rate ofHBV perinatal transmission and supporting the WHO recommendation to vaccinate at birth against hepatitis B.
References
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Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
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Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
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The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
TL;DR: HBV and HCV infections account for the majority of cirrhosis and primary liver cancer throughout most of the world, highlighting the need for programs to prevent new infections and provide medical management and treatment for those already infected.
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Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
TL;DR: Further studies are needed to investigate other viral factors (eg, HBV genotype/mutant, occult HBV, HIV coinfection) and preventable or treatable comorbidities ( eg, obesity, diabetes) in the HCC risk in cirrhosis.