Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
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Journal ArticleDOI
Predominance of HBV Genotype B and HDV Genotype 1 in Vietnamese Patients with Chronic Hepatitis.
Nghiem Xuan Hoan,Mirjam Hoechel,Alexandru Tomazatos,Chu Xuan Anh,Srinivas Reddy Pallerla,Le Thi Kieu Linh,Mai Thanh Binh,Bui Tien Sy,Nguyen Linh Toan,Heiner Wedemeyer,C.-Thomas Bock,Peter G. Kremsner,Christian Meyer,Le Huu Song,Thirumalaisamy P. Velavan +14 more
TL;DR: In this article, the presence of hepatitis B viral DNA and hepatitis delta RNA was determined by phylogenetically reconstructed and vaccine escape mutations in the determinant region of HBV were elucidated.
Journal ArticleDOI
The influence of ethnicity on disease outcome in patients with chronic hepatitis B infection.
Özgür M Koc,Geert Robaeys,Geert Robaeys,Beytullah Yildirim,Dirk Posthouwer,Niel Hens,Niel Hens,Ger H. Koek,Ger H. Koek +8 more
TL;DR: In this study, foreign‐born chronic hepatitis B (CHB) patients were associated with more advanced HBV‐related liver disease with 27% having cirrhosis, however, ethnicity was not associated with Cirrhosis when SES was included in the multivariate analysis.
Dissertation
The role of the programmed cell death (PD-1) pathway in the immunopathogenesis of chronic hepatitis B infection
TL;DR: These studies demonstrate that the Hepatitis B virus itself upregulates PDL1 expression on infected hepatocytes in vitro and in doing so, are able to alter the balance between cytolytic and non-cy tolytic CD8+ T-cell effector functions favouring chronicity of infection.
Journal ArticleDOI
Tenofovir Alafenamide Fumarate, Tenofovir Disoproxil Fumarate and Entecavir: Which is the Most Effective Drug for Chronic Hepatitis B? A Systematic Review and Meta-analysis
TL;DR: The virological response in TDF-treatedCHB patients was superior to that in ETV-treated CHB patients, but there was no significant difference between TAF and TDF.
Journal ArticleDOI
A hook-effect-free homogeneous light-initiated chemiluminescence assay: is it reliable for screening and the quantification of the hepatitis B surface antigen?
TL;DR: A hook-effect-free homogeneous quantitative HBsAg assay based on the light-initiated chemiluminescence immunoassay (LICA) provides a reliable tool for screening for HBV infection and quantifyingHBsAg.
References
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Journal ArticleDOI
Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
Journal ArticleDOI
Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
Journal ArticleDOI
The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
TL;DR: HBV and HCV infections account for the majority of cirrhosis and primary liver cancer throughout most of the world, highlighting the need for programs to prevent new infections and provide medical management and treatment for those already infected.
Journal ArticleDOI
Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
TL;DR: Further studies are needed to investigate other viral factors (eg, HBV genotype/mutant, occult HBV, HIV coinfection) and preventable or treatable comorbidities ( eg, obesity, diabetes) in the HCC risk in cirrhosis.