Journal ArticleDOI
Natural history of chronic hepatitis B: Special emphasis on disease progression and prognostic factors
TLDR
There is a growing understanding of viral, host and environmental factors influencing disease progression, which ultimately could improve the management of chronic hepatitis B.About:
This article is published in Journal of Hepatology.The article was published on 2008-02-01. It has received 1172 citations till now. The article focuses on the topics: HBeAg & Hepatitis B.read more
Citations
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Quasispecies structure, cornerstone of hepatitis B virus infection: Mass sequencing approach
TL;DR: The information regarding HBV variability is updated and a summary of the various NGS approaches available for research in this virus is presented, including an analysis of the clinical implications of HBV variants and their study by NGS.
Journal ArticleDOI
Aiming for the elimination of viral hepatitis in Australia, New Zealand, and the Pacific Islands and Territories: Where are we now and barriers to meeting World Health Organization targets by 2030
J. Howell,Alisa Pedrana,Benjamin C Cowie,Benjamin C Cowie,Joseph Doyle,Joseph Doyle,Aneley Getahun,James Ward,E.J. Gane,Chris Cunningham,Jack Wallace,Jack Wallace,Alice Lee,Jioji Malani,Alexander J. Thompson,Alexander J. Thompson,Margaret Hellard,Margaret Hellard +17 more
TL;DR: This review highlights the latest evidence in viral hepatitis epidemiology and explores the health resources available to combat viral hepatitis, focusing on the major challenges and critical needs to achieve elimination in Australia, New Zealand, and Pacific Island Countries and Territories.
Journal ArticleDOI
The Role of Interferon in Hepatitis B Therapy
TL;DR: Future studies need to address whether specific virologic benchmarks can guide individualized decisions concerning therapy continuation and whether peginterferon combined with new potent nucleos(t)ide analogues improves treatment outcomes.
Journal ArticleDOI
Hepatocellular carcinoma in chronic HBV-HCV co-infection is correlated to fibrosis and disease duration
Rosa Zampino,Maria Antonietta Pisaturo,Grazia Cirillo,Aldo Marrone,Margherita Macera,Luca Rinaldi,Maria Stanzione,Emanuele Durante-Mangoni,Ivan Gentile,Evangelista Sagnelli,Giuseppe Signoriello,Emanuele Miraglia del Giudice,L. E. Adinolfi,Nicola Coppola +13 more
TL;DR: HCC was more frequent in patients with HBV-HCV co-infection, than in those withHBV or HCV mono- Infection; possible associated risk factors for HCC development seem a long duration of disease, high levels of fibrosis and carbohydrate intolerance.
Journal ArticleDOI
Prevalence of hepatitis B virus and risk factors in Brazilian non-injecting drug users
Renata Ferreira,Fabiana P Rodrigues,Sheila Araújo Teles,Carmen Luci Rodrigues Lopes,Ana Rita Coimbra Motta-Castro,Antonia Carlos Magalhaes Novais,Francisco José Dutra Souto,Regina Maria Bringel Martins +7 more
TL;DR: The overall and occult HBV infection prevalence rates were determined in a large population of non‐injecting drug users in the Central‐West region of Brazil and indicated that preventive interventions are needed for both sexual and drug‐related high‐risk behavior.
References
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Measuring inconsistency in meta-analyses
TL;DR: A new quantity is developed, I 2, which the authors believe gives a better measure of the consistency between trials in a meta-analysis, which is susceptible to the number of trials included in the meta- analysis.
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Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level.
Chien-Jen Chen,Hwai I. Yang,Jun Su,C.-L. Jen,San Lin You,Sheng-Nan Lu,Guan-Tarn Huang,Uchenna H. Iloeje +7 more
TL;DR: Elevated serum HBV DNA level (> or =10,000 copies/mL) is a strong risk predictor of hepatocellular carcinoma independent of HBeAg, serum alanine aminotransferase level, and liver cirrhosis.
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Chronic hepatitis B
Anna S. Lok,Brian J. McMahon +1 more
TL;DR: These guidelines have been written to assist physicians and other health care providers in the recognition, diagnosis, and management of patients chronically infected with the hepatitis B virus (HBV).
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The contributions of hepatitis B virus and hepatitis C virus infections to cirrhosis and primary liver cancer worldwide
TL;DR: HBV and HCV infections account for the majority of cirrhosis and primary liver cancer throughout most of the world, highlighting the need for programs to prevent new infections and provide medical management and treatment for those already infected.
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Hepatocellular carcinoma in cirrhosis: incidence and risk factors.
TL;DR: Further studies are needed to investigate other viral factors (eg, HBV genotype/mutant, occult HBV, HIV coinfection) and preventable or treatable comorbidities ( eg, obesity, diabetes) in the HCC risk in cirrhosis.