Neurofilaments in disease: what do we know?
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TLDR
There is mounting evidence that neurofilament light chain and phosphorylated neurofilaments are abnormal in a host of neurodegenerative diseases and what the authors know about how these biomarkers relate to in vivo white matter pathology and each other is examined.About:
This article is published in Current Opinion in Neurobiology.The article was published on 2020-04-01 and is currently open access. It has received 40 citations till now. The article focuses on the topics: Neurofilament.read more
Citations
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CSF biomarkers of neuroinflammation in distinct forms and subtypes of neurodegenerative dementia.
Samir Abu-Rumeileh,Petra Steinacker,Barbara Polischi,Angela Mammana,Anna Bartoletti-Stella,Patrick Oeckl,Simone Baiardi,Corrado Zenesini,André Huss,Pietro Cortelli,Sabina Capellari,Markus Otto,Piero Parchi +12 more
TL;DR: CSF glial markers of neuroinflammation demonstrate limited diagnostic value but have some potential for monitoring the clinical and, possibly, preclinical phases of NDs.
Journal ArticleDOI
Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease.
Stephanie A. Schultz,Jeremy F. Strain,Adedamola Adedokun,Qing Wang,Oliver Preische,Jens Kuhle,Shaney Flores,Sarah Keefe,Aylin Dincer,Beau M. Ances,Sarah B. Berman,Adam M. Brickman,David M. Cash,Jasmeer P. Chhatwal,Carlos Cruchaga,Michael Ewers,Nick N. Fox,Bernardino Ghetti,Alison Goate,Neill R. Graff-Radford,Jason Hassenstab,Russ C. Hornbeck,Clifford R. Jack,Keith A. Johnson,Nelly Joseph-Mathurin,Celeste M. Karch,Robert A. Koeppe,Athene Lee,Johannes Levin,Colin L. Masters,Eric McDade,Richard J. Perrin,Christopher C. Rowe,Stephen Salloway,Andrew J. Saykin,Reisa A. Sperling,Yi Su,Victor L. Villemagne,Jonathan Vöglein,Michael W. Weiner,Chengjie Xiong,Anne M. Fagan,John C. Morris,Randall J. Bateman,Tammie L.S. Benzinger,Mathias Jucker,Brian A. Gordon +46 more
TL;DR: It is demonstrated that blood-based NfL levels reflect WM integrity and supports the view that blood levels of Nf L are predictive of WM damage in the brain, and is a critical result in improving the interpretability of N fL as a marker of brain integrity.
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Structural heterogeneity of cellular K5/K14 filaments as revealed by cryo-electron microscopy
Miriam Weber,Matthias Eibauer,Suganya Sivagurunathan,Thomas M. Magin,Robert D. Goldman,Ohad Medalia +5 more
TL;DR: In this paper, the authors analyzed the structure of 5/keratin 14 filaments within ghost mouse keratinocytes by cryo-electron microscopy and cryoelectron tomography.
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Evaluating resting-state BOLD variability in relation to biomarkers of preclinical Alzheimer's disease.
Peter R. Millar,Beau M. Ances,Brian A. Gordon,Tammie L.S. Benzinger,Anne M. Fagan,John C. Morris,David A. Balota +6 more
TL;DR: BOLD variability may be sensitive to preclinical pathology, including amyloidosis and neurodegeneration in AD-sensitive areas, and relationships with hippocampal volume and cortical thickness survived correction for cardiovascular health and also contributed to age-related differences in BOLD variability.
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Cerebrospinal fluid neurofilament light chain is a marker of aging and white matter damage
Karin L. Meeker,Omar H. Butt,Brian A. Gordon,Anne M. Fagan,Suzanne E. Schindler,John C. Morris,Tammie L.S. Benzinger,Beau M. Ances +7 more
TL;DR: In this article , the relative importance of brain tissue volume, age, and AD marker status (i.e., APOE genotype, brain amyloidosis, tauopathy, and cognitive status) in predicting CSF NfL was investigated.
References
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Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS
Mariely DeJesus-Hernandez,Ian R. A. Mackenzie,Bradley F. Boeve,Adam L. Boxer,Matt Baker,Nicola J. Rutherford,Alexandra M. Nicholson,Ni Cole A. Finch,Heather C. Flynn,Jennifer Adamson,Naomi Kouri,Aleksandra Wojtas,Pheth Sengdy,Ging-Yuek Robin Hsiung,Anna Karydas,William W. Seeley,Keith A. Josephs,Giovanni Coppola,Daniel H. Geschwind,Zbigniew K. Wszolek,Howard Feldman,Howard Feldman,David S. Knopman,Ronald C. Petersen,Bruce L. Miller,Dennis W. Dickson,Kevin B. Boylan,Neill R. Graff-Radford,Rosa Rademakers +28 more
TL;DR: It is found that repeat expansion in C9ORF72 is a major cause of both FTD and ALS, suggesting multiple disease mechanisms.
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Diffusion tensor imaging: Concepts and applications
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TL;DR: The concepts behind diffusion tensor imaging are reviewed and potential applications, including fiber tracking in the brain, which, in combination with functional MRI, might open a window on the important issue of connectivity.
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Intermediate filaments: structure, dynamics, function, and disease.
Elaine Fuchs,Klaus Weber +1 more
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Estimating the global incidence of traumatic brain injury
Michael C. Dewan,Abbas Rattani,Saksham Gupta,Ronnie E. Baticulon,Ya-Ching Hung,Maria Punchak,Amit Agrawal,Amos Olufemi Adeleye,Mark G. Shrime,Andres M. Rubiano,Jeffrey V. Rosenfeld,Kee B. Park +11 more
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Neurofilaments as biomarkers in neurological disorders
Michael Khalil,Charlotte E. Teunissen,Markus Otto,Fredrik Piehl,Maria Pia Sormani,Thomas Gattringer,Christian Barro,Ludwig Kappos,Manuel Comabella,Franz Fazekas,Axel Petzold,Kaj Blennow,Kaj Blennow,Henrik Zetterberg,Jens Kuhle +14 more
TL;DR: How technological advances have enabled the detection of neurofilament proteins in the blood is considered, and how these proteins consequently have the potential to be easily measured biomarkers of neuroaxonal injury in various neurological conditions are discussed.