Journal ArticleDOI
Oxidative stress in Alzheimer's disease
Ved Chauhan,Abha Chauhan +1 more
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TLDR
This review discusses free radical-mediated damage to the biochemical components involved in the pathology and clinical symptoms of Alzheimer's disease and explains how amyloid beta-protein, microtubule-associated protein tau, presenilins, apolipoprotein E, mitochondria and proteases play a role in increasing oxidative stress in AD.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 318 citations till now. The article focuses on the topics: Oxidative stress & Neurofibrillary tangle.read more
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Journal ArticleDOI
Tricyclodecan-9-yl-Xanthogenate (D609): Mechanism of Action and Pharmacological Applications
Aashiq Hussain Bhat,Khalid Bashir Dar,Andleeb Khan,Saeed Alshahrani,Sultan Alshehri,Mohamed M. Ghoneim,Prawez Alam,Faiyaz Shakeel +7 more
TL;DR: A comprehensive mechanistic insight is provided into D609, including its chemistry, mechanism of action, and regulation of various pharmacological activities, which demonstrates promising results in reducing atherosclerotic plaque formation, post-stroke cerebral infarction, and cancer progression.
Serbest rad‹kaller ve ant‹oks‹dan gidalarla ‹nh‹b‹syonu free radicals and their inhibitions with antioxidant foods
TL;DR: The antioxidants from food sources or supplements appear to be promising for successful aging by improving im- mune function, and reducing the risk of several chronic diseases, such as cardiovascular disease and cancer.
Posted ContentDOI
Consequences of endogenous and virally-induced hyperphosphorylated tau on behavior and cognition in a rat model of Alzheimer’s disease
Michael Kelberman,Claire R. Anderson,Eli Chlan,Eli Chlan,Jacki M. Rorabaugh,Katharine E. McCann,David Weinshenker +6 more
TL;DR: In this paper, the locus coeruleus (LC) is one of the earliest brain regions to accumulate hyperphosphorylated tau, but a lack of animal models that recapitulate this pathology has hampered our ability to understand its contributions to the pathophysiology of Alzheimer9s disease (AD).
Journal ArticleDOI
Amino acid-functionalized chitosan beads for in vitro copper ions uptake in the presence of histidine
TL;DR: In this paper, the in vitro ability of chitosan-based beads to uptake copper ions in the presence of histidine residues was evaluated by scanning electron microscopy, X-ray diffraction and Fourier transform infrared spectroscopy.
References
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Journal ArticleDOI
Aging: A Theory Based on Free Radical and Radiation Chemistry
TL;DR: It seems possible that one factor in aging may be related to deleterious side attacks of free radicals (which are normally produced in the course of cellular metabolism) on cell constituents.
Journal ArticleDOI
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Jie Kang,H. G. Lemaire,A. Unterbeck,J. M. Salbaum,Colin L. Masters,K.-H. Grzeschik,Gerd Multhaup,Konrad Beyreuther,Benno Müller-Hill +8 more
TL;DR: An apparently full-length complementary DNA clone coding for the A4 polypeptide is isolated and sequenced and suggests that the cerebral amyloid deposited in Alzheimer's disease and aged Down's syndrome is caused by aberrant catabolism of a cell-surface receptor.
Journal ArticleDOI
Amyloid plaque core protein in Alzheimer disease and Down syndrome
Colin L. Masters,Gail Simms,Nicola A. Weinman,Gerd Multhaup,Brian L. McDonald,Konrad Beyreuther +5 more
TL;DR: The shared 4-kDa subunit indicates a common origin for the amyloids of the plaque core and of the congophilic angiopathy of Alzheimer disease and Down syndrome.
Journal ArticleDOI
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
Robert Vassar,Brian D. Bennett,Safura Babu-Khan,Steve Kahn,Elizabeth A. Mendiaz,Paul Denis,David B. Teplow,Sandra Ross,Patricia Amarante,Richard Loeloff,Yi Luo,Seth Fisher,Janis Fuller,Steven P. Edenson,Jackson Lile,Mark A. Jarosinski,Anja Leona Biere,Eileen Curran,Teresa L. Burgess,Jean Claude Louis,Frank H. Collins,James J. S. Treanor,Gary Rogers,Martin Citron +23 more
TL;DR: Overexpression of a transmembrane aspartic protease, termed BACE (for beta-site APP-cleaving enzyme) increased the amount of beta-secretase cleavage products, and these were cleaved exactly and only at known beta- secretase positions.
Journal ArticleDOI
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
Lindsay A. Farrer,L. Adrienne Cupples,Jonathan L. Haines,Bradley T. Hyman,Walter A. Kukull,Richard Mayeux,Richard H. Myers,Margaret A. Pericak-Vance,Neil Risch,Cornelia M. van Duijn +9 more
TL;DR: The APOE∈4 allele represents a major risk factor for AD in all ethnic groups studied, across all ages between 40 and 90 years, and in both men and women.
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