Journal ArticleDOI
Oxidative stress in Alzheimer's disease
Ved Chauhan,Abha Chauhan +1 more
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TLDR
This review discusses free radical-mediated damage to the biochemical components involved in the pathology and clinical symptoms of Alzheimer's disease and explains how amyloid beta-protein, microtubule-associated protein tau, presenilins, apolipoprotein E, mitochondria and proteases play a role in increasing oxidative stress in AD.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 318 citations till now. The article focuses on the topics: Oxidative stress & Neurofibrillary tangle.read more
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Importance and management of micronutrient deficiencies in patients with Alzheimer's disease
TL;DR: A literature review on the major nutrients that are related to AD, including selenium, vitamins C and E, transition metals, vitamin D, B-complex vitamins, and omega-3 fatty acids is performed.
Journal ArticleDOI
Decreasing oxidative stress and neuroinflammation with a multifunctional peptide rescues memory deficits in mice with Alzheimer disease
Wei-wei Zhou,Shuai Lu,Ya-jing Su,Di Xue,Xiao-lin Yu,Shao-wei Wang,He Zhang,Peng-xin Xu,Xi-xiu Xie,Rui-tian Liu +9 more
TL;DR: It is found that this peptide significantly improved spatial memory and reduced the amyloid plaque burden and soluble and insoluble Aβ levels and this multifunctional peptide has therapeutic potential for an Aβ-targeted treatment of AD.
Journal ArticleDOI
Magnolol Protects Against Oxidative Stress-Mediated Neural Cell Damage by Modulating Mitochondrial Dysfunction and PI3K/Akt Signaling
TL;DR: It is found that magnolol pretreatment significantly attenuated acrolein-induced oxidative stress through inhibiting reactive oxygen species accumulation caused by intracellular glutathione depletion and nicotinamide adenine dinucleotide phosphate oxidase activation and prolongs SH-SY5Y cell survival through regulating JNK/mitochondria/caspase, PI3k/MEK/ERK, and PI3K/Akt/FoxO1 signaling pathways.
Journal ArticleDOI
Punica granatum protects against oxidative stress in PC12 cells and oxidative stress-induced Alzheimer's symptoms in mice.
Soo Jung Choi,Ju Hyun Lee,Ho Jin Heo,Hong-Yon Cho,Hye Kyung Kim,Chang-Ju Kim,Myeong Ok Kim,Soo Hwan Suh,Dong-Hoon Shin +8 more
TL;DR: The results of this study suggest that the ethanol extract of P. granatum mitigated H₂O⁂-induced oxidative stress in PC12 cells, and inhibited neuronal cell death caused by Aβ-induced antioxidant stress and A β-induced learning and memory deficiency.
Journal ArticleDOI
Covalent cross-linking of glutathione and carnosine to proteins by 4-oxo-2-nonenal.
TL;DR: It is shown that ONE becomes more protein-reactive in the presence of GSH, whereas protein modification by 4-hydroxy-2-nonenal is inhibited by GSH.
References
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Journal ArticleDOI
Aging: A Theory Based on Free Radical and Radiation Chemistry
TL;DR: It seems possible that one factor in aging may be related to deleterious side attacks of free radicals (which are normally produced in the course of cellular metabolism) on cell constituents.
Journal ArticleDOI
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
Jie Kang,H. G. Lemaire,A. Unterbeck,J. M. Salbaum,Colin L. Masters,K.-H. Grzeschik,Gerd Multhaup,Konrad Beyreuther,Benno Müller-Hill +8 more
TL;DR: An apparently full-length complementary DNA clone coding for the A4 polypeptide is isolated and sequenced and suggests that the cerebral amyloid deposited in Alzheimer's disease and aged Down's syndrome is caused by aberrant catabolism of a cell-surface receptor.
Journal ArticleDOI
Amyloid plaque core protein in Alzheimer disease and Down syndrome
Colin L. Masters,Gail Simms,Nicola A. Weinman,Gerd Multhaup,Brian L. McDonald,Konrad Beyreuther +5 more
TL;DR: The shared 4-kDa subunit indicates a common origin for the amyloids of the plaque core and of the congophilic angiopathy of Alzheimer disease and Down syndrome.
Journal ArticleDOI
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
Robert Vassar,Brian D. Bennett,Safura Babu-Khan,Steve Kahn,Elizabeth A. Mendiaz,Paul Denis,David B. Teplow,Sandra Ross,Patricia Amarante,Richard Loeloff,Yi Luo,Seth Fisher,Janis Fuller,Steven P. Edenson,Jackson Lile,Mark A. Jarosinski,Anja Leona Biere,Eileen Curran,Teresa L. Burgess,Jean Claude Louis,Frank H. Collins,James J. S. Treanor,Gary Rogers,Martin Citron +23 more
TL;DR: Overexpression of a transmembrane aspartic protease, termed BACE (for beta-site APP-cleaving enzyme) increased the amount of beta-secretase cleavage products, and these were cleaved exactly and only at known beta- secretase positions.
Journal ArticleDOI
Effects of Age, Sex, and Ethnicity on the Association Between Apolipoprotein E Genotype and Alzheimer Disease: A Meta-analysis
Lindsay A. Farrer,L. Adrienne Cupples,Jonathan L. Haines,Bradley T. Hyman,Walter A. Kukull,Richard Mayeux,Richard H. Myers,Margaret A. Pericak-Vance,Neil Risch,Cornelia M. van Duijn +9 more
TL;DR: The APOE∈4 allele represents a major risk factor for AD in all ethnic groups studied, across all ages between 40 and 90 years, and in both men and women.
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