Journal ArticleDOI
Oxidative stress in Alzheimer's disease
Ved Chauhan,Abha Chauhan +1 more
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TLDR
This review discusses free radical-mediated damage to the biochemical components involved in the pathology and clinical symptoms of Alzheimer's disease and explains how amyloid beta-protein, microtubule-associated protein tau, presenilins, apolipoprotein E, mitochondria and proteases play a role in increasing oxidative stress in AD.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 318 citations till now. The article focuses on the topics: Oxidative stress & Neurofibrillary tangle.read more
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Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
Eric Tönnies,Eugenia Trushina +1 more
TL;DR: The role of oxidative stress in synaptic dysfunction in AD, innovative therapeutic strategies evolved based on a better understanding of the complexity of molecular mechanisms of AD, and the dual role ROS play in health and disease are discussed.
Journal ArticleDOI
Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease.
Rosa Resende,Paula I. Moreira,Teresa Proença,Atul Deshpande,Jorge Busciglio,Cláudia Pereira,Catarina R. Oliveira +6 more
TL;DR: In this article, the authors investigated the role of oxidative stress in the early stages of Alzheimer's disease in a triple-transgenic mouse model and showed that the levels of antioxidants, namely, reduced glutathione and vitamin E, are decreased and the extent of lipid peroxidation is increased.
Journal ArticleDOI
Antioxidant activities and phenolics content of eight species of seaweeds from north Borneo
Patricia Matanjun,Suhaila Mohamed,Noordin Mohamed Mustapha,Kharidah Muhammad,Cheng Hwee Ming +4 more
TL;DR: There was a strong correlation between the reducing power and the total phenolic content of the seaweeds methanolic dry extracts and these seaweeds could be potential rich sources of natural antioxidants.
Journal ArticleDOI
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease
Katja M. Kanninen,Riikka Heikkinen,Tarja Malm,Taisia Rolova,Susanna Kuhmonen,Hanna Leinonen,Seppo Ylä-Herttuala,Heikki Tanila,Anna-Liisa Levonen,Milla Koistinaho,Jari Koistinaho +10 more
TL;DR: The data indicate that significant reductions in spatial learning deficits of aged APP/PS1 mice in a Morris Water Maze can be achieved by modulating levels of NRF2 in the brain and suggest that the Nrf2-ARE pathway may represent a potential therapeutic strategy to pursue in AD in humans, particularly in view of the multiple mechanisms by which Nrf1 can exert its protective effects.
Journal ArticleDOI
Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats.
Roberta Schmatz,Cinthia M. Mazzanti,Roselia Maria Spanevello,Naiara Stefanello,Jessié Martins Gutierres,Maísa Corrêa,Michelle Melgarejo da Rosa,Maribel Antonello Rubin,Maria Rosa Chitolina Schetinger,Vera Maria Morsch +9 more
TL;DR: It is shown that treatment with resveratrol prevents the increase in AChE activity and consequently memory impairment in diabetic rats, demonstrating that this compound can modulate cholinergic neurotransmission and consequently improve cognition.
References
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Journal ArticleDOI
Superoxide dismutase activity in Alzheimer's disease: possible mechanism for paired helical filament formation☆
TL;DR: The elevation in SOD-1 activity observed in the familial Alzheimer's patients supports the theory that paired helical filaments are synthesized in Alzheimer's disease by free radical hydroxylation of proline residues in paired helicals filament precursor protein(s).
Journal ArticleDOI
Amyloid precursor proteins inhibit heme oxygenase activity and augment neurotoxicity in Alzheimer's disease.
Masaaki Takahashi,Sylvain Doré,Christopher D. Ferris,Taisuke Tomita,Akira Sawa,Herman Wolosker,David R. Borchelt,Takeshi Iwatsubo,Seong Hun Kim,Gopal Thinakaran,Sangram S. Sisodia,Solomon H. Snyder +11 more
TL;DR: It is reported that APP and APLP bind to heme oxygenase (HO), an enzyme whose product, bilirubin, is antioxidant and neuroprotective, indicating that augmented neurotoxicity caused by APP-HO interactions may contribute to neuronal cell death in Alzheimer's disease.
Journal ArticleDOI
β-Amyloid protein-dependent nitric oxide production from microglial cells and neurotoxicity
M Sunamoto,K Ohnishi,Y Ichimori +2 more
TL;DR: It is likely that A beta-induced NO production by microglial cells is one mechanism of the neuronal death in AD.
Journal ArticleDOI
The Ginkgo biloba extract EGb 761 rescues the PC12 neuronal cells from β-amyloid-induced cell death by inhibiting the formation of β-amyloid-derived diffusible neurotoxic ligands
TL;DR: Results indicate that the terpenoid and flavonoid constituents of EGb 761, acting probably in combination with components present in HE 208, are responsible for rescuing the neuronal cells from Aβ-induced apoptosis and cell death; their mechanism of action being distinct of their antioxidant properties.
Journal ArticleDOI
Brain Regional Quantification of F-Ring and D-/E-Ring Isoprostanes and Neuroprostanes in Alzheimer’s Disease
Erin E. Reich,William R. Markesbery,L. Jackson Roberts,Larry L. Swift,Jason D. Morrow,Thomas J. Montine +5 more
TL;DR: Results from in situ techniques are extended by quantifying significantly greater free radical damage to the DHA-containing compartments in cerebrum in AD patients than controls, and suggest that one mechanism of increased oxidative stress may be diminished reducing capacity in DHA.
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