Journal ArticleDOI
Oxidative stress in Alzheimer's disease
Ved Chauhan,Abha Chauhan +1 more
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TLDR
This review discusses free radical-mediated damage to the biochemical components involved in the pathology and clinical symptoms of Alzheimer's disease and explains how amyloid beta-protein, microtubule-associated protein tau, presenilins, apolipoprotein E, mitochondria and proteases play a role in increasing oxidative stress in AD.About:
This article is published in Pathophysiology.The article was published on 2006-08-01. It has received 318 citations till now. The article focuses on the topics: Oxidative stress & Neurofibrillary tangle.read more
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Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
Eric Tönnies,Eugenia Trushina +1 more
TL;DR: The role of oxidative stress in synaptic dysfunction in AD, innovative therapeutic strategies evolved based on a better understanding of the complexity of molecular mechanisms of AD, and the dual role ROS play in health and disease are discussed.
Journal ArticleDOI
Brain oxidative stress in a triple-transgenic mouse model of Alzheimer disease.
Rosa Resende,Paula I. Moreira,Teresa Proença,Atul Deshpande,Jorge Busciglio,Cláudia Pereira,Catarina R. Oliveira +6 more
TL;DR: In this article, the authors investigated the role of oxidative stress in the early stages of Alzheimer's disease in a triple-transgenic mouse model and showed that the levels of antioxidants, namely, reduced glutathione and vitamin E, are decreased and the extent of lipid peroxidation is increased.
Journal ArticleDOI
Antioxidant activities and phenolics content of eight species of seaweeds from north Borneo
Patricia Matanjun,Suhaila Mohamed,Noordin Mohamed Mustapha,Kharidah Muhammad,Cheng Hwee Ming +4 more
TL;DR: There was a strong correlation between the reducing power and the total phenolic content of the seaweeds methanolic dry extracts and these seaweeds could be potential rich sources of natural antioxidants.
Journal ArticleDOI
Intrahippocampal injection of a lentiviral vector expressing Nrf2 improves spatial learning in a mouse model of Alzheimer's disease
Katja M. Kanninen,Riikka Heikkinen,Tarja Malm,Taisia Rolova,Susanna Kuhmonen,Hanna Leinonen,Seppo Ylä-Herttuala,Heikki Tanila,Anna-Liisa Levonen,Milla Koistinaho,Jari Koistinaho +10 more
TL;DR: The data indicate that significant reductions in spatial learning deficits of aged APP/PS1 mice in a Morris Water Maze can be achieved by modulating levels of NRF2 in the brain and suggest that the Nrf2-ARE pathway may represent a potential therapeutic strategy to pursue in AD in humans, particularly in view of the multiple mechanisms by which Nrf1 can exert its protective effects.
Journal ArticleDOI
Resveratrol prevents memory deficits and the increase in acetylcholinesterase activity in streptozotocin-induced diabetic rats.
Roberta Schmatz,Cinthia M. Mazzanti,Roselia Maria Spanevello,Naiara Stefanello,Jessié Martins Gutierres,Maísa Corrêa,Michelle Melgarejo da Rosa,Maribel Antonello Rubin,Maria Rosa Chitolina Schetinger,Vera Maria Morsch +9 more
TL;DR: It is shown that treatment with resveratrol prevents the increase in AChE activity and consequently memory impairment in diabetic rats, demonstrating that this compound can modulate cholinergic neurotransmission and consequently improve cognition.
References
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Journal ArticleDOI
Oxidative damage is the earliest event in Alzheimer disease.
Akihiko Nunomura,George Perry,Gjumrakch Aliev,Keisuke Hirai,Keisuke Hirai,Atsushi Takeda,Elizabeth Balraj,Paul K. Jones,Hossein A. Ghanbari,Takafumi Wataya,Shun Shimohama,Shigeru Chiba,Craig S. Atwood,Robert B. Petersen,Mark A. Smith +14 more
TL;DR: The observations indicate that increased oxidative damage is an early event in AD that decreases with disease progression and lesion formation and suggest that AD is associated with compensatory changes that reduce damage from reactive oxygen.
Journal ArticleDOI
Vitamin E and Donepezil for the Treatment of Mild Cognitive Impairment
Ronald C. Petersen,Ronald G. Thomas,Michael Grundman,David A. Bennett,Rachelle S. Doody,Steven H. Ferris,Douglas Galasko,Shelia Jin,Jeffrey Kaye,Allan I. Levey,Eric Pfeiffer,Mary Sano,Christopher H. van Dyck,Leon J. Thal +13 more
TL;DR: Vitamin E had no benefit in patients with mild cognitive impairment and donepezil therapy was associated with a lower rate of progression to Alzheimer's disease during the first 12 months of treatment, a finding supported by the secondary outcome measures.
Journal ArticleDOI
Statins and the risk of dementia.
Hershel Jick,Gwen L. Zornberg,Gwen L. Zornberg,Susan S. Jick,Sudha Seshadri,David A. Drachman +5 more
TL;DR: Individuals of 50 years and older who were prescribed statins had a substantially lowered risk of developing dementia, independent of the presence or absence of untreated hyperlipidaemia, or exposure to nonstatin LLAs.
Journal ArticleDOI
Aging, energy, and oxidative stress in neurodegenerative diseases.
TL;DR: Potential therapeutic approaches include glutamate release inhibitors, excitatory amino acid antagonists, strategies to improve mitochondrial function, free radical scavengers, and trophic factors, which appear promising in experimental studies and are now being applied to human studies.
Journal ArticleDOI
A68: a major subunit of paired helical filaments and derivatized forms of normal Tau
TL;DR: The major subunits of a class of PHFs are A68 proteins and the excessive or inappropriate phosphorylation of normal tau may change its apparent Mr, thus transforming tau into A68.
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