Journal ArticleDOI
Priorities in Parkinson's disease research
Wassilios G. Meissner,Wassilios G. Meissner,Mark Frasier,Thomas Gasser,Christopher G. Goetz,Andres M. Lozano,Paola Piccini,Jose A. Obeso,Olivier Rascol,Anthony H.V. Schapira,Valerie Voon,David M. Weiner,François Tison,François Tison,Erwan Bezard +14 more
Reads0
Chats0
TLDR
This Review describes the most promising biological targets and therapeutic agents that are currently being assessed to address treatment goals of Parkinson's disease.Abstract:
The loss of dopaminergic neurons in the substantia nigra pars compacta leads to the characteristic motor symptoms of Parkinson's disease: bradykinesia, rigidity and resting tremors. Although these symptoms can be improved using currently available dopamine replacement strategies, there is still a need to improve current strategies of treating these symptoms, together with a need to alleviate non-motor symptoms of the disease. Moreover, treatments that provide neuroprotection and/or disease-modifying effects remain an urgent unmet clinical need. This Review describes the most promising biological targets and therapeutic agents that are currently being assessed to address these treatment goals. Progress will rely on understanding genetic mutations or susceptibility factors that lead to Parkinson's disease, better translation between preclinical animal models and clinical research, and improving the design of future clinical trials.read more
Citations
More filters
Journal ArticleDOI
GTP-binding inhibitors increase LRRK2-linked ubiquitination and Lewy body-like inclusions.
Joseph M. Thomas,Joseph M. Thomas,Xiaobo Wang,Xiaobo Wang,Gongbo Guo,Tianxia Li,Bingling Dai,Leslie G. Nucifora,Frederick C. Nucifora,Zhaohui Liu,Fengtian Xue,Chun Feng Liu,Christopher A. Ross,Wanli W. Smith +13 more
TL;DR: It is demonstrated that LRRK2 GTP‐binding activity is critical in L RRK2‐linked ubiquitination and aggregation formation and provides novel insight into the LRRk2‐ linked Lewy body‐like inclusion formation underlying PD pathogenesis.
Journal ArticleDOI
Validation of a New Scoring Scale for Behavioral Assessment of L-Dopa-Induced Dyskinesia in the Rat: A New Tool for Early Decision-Making in Drug Development.
Simon Loiodice,Anne-Sophie Denibaud,Wendy Deffains,Magali Alix,Pierre Montagne,Marine Seffals,Christophe Drieu La Rochelle +6 more
TL;DR: A simplified method, able to reflect different levels of severity in the assessment of LID and, thus, provide a reliable tool for drug discovery is validated.
Journal ArticleDOI
Neurotherapeutic Effects of Bee Venom in a Rotenone-Induced Mouse Model of Parkinson’s Disease
M. K. Rakha,R. A. Tawfiq,M. M. Sadek,Mohammed Anwer,S. M. Salama,A. F. Mohamed,M. G. El-Hendy,Sh. E. El-Said,N. M. Ahmed,K. S. Mekawi,A. M. Abd El-Aziz,M. M. Elmazar +11 more
TL;DR: In this paper, the authors evaluated the neurotherapeutic effects of Egyptian bee venom against PD hallmarks in a PD mouse model, i.e., six subcutaneous injections of 1.5 mg/kg of rotenone at 48hlong intervals induced significant reductions in the motor strength and motor coordination.
DissertationDOI
Targeting neurotransmitter receptors for central nervous system therapeutics : from molecular signalling to behavioural pharmacology
TL;DR: In this paper, the author's publications that were not peer-reviewed (such as conference proceeedings) are referenced in the text by numbers in superscript (1, 2, 3,... etc.) and listed in the Bibliography at the end of the thesis.
Journal ArticleDOI
Pharmacological intervention of early neuropathy in neurodegenerative diseases
TL;DR: Current understanding on the system-wide transcriptional dysregulation that is likely associated with early neuropathy shown in various neurodegenerative diseases is reviewed and the possible future developments of pharmaceutical therapeutics are discussed.
References
More filters
Journal ArticleDOI
Parkinson’s disease: clinical features and diagnosis
TL;DR: A thorough understanding of the broad spectrum of clinical manifestations of PD is essential to the proper diagnosis of the disease and genetic mutations or variants, neuroimaging abnormalities and other tests are potential biomarkers that may improve diagnosis and allow the identification of persons at risk.
Journal ArticleDOI
Diagnosis and management of dementia with Lewy bodies: Third report of the DLB Consortium
Ian G. McKeith,Ian G. McKeith,Dennis W. Dickson,James Lowe,Murat Emre,John T. O'Brien,Howard Feldman,Jeffrey L. Cummings,John E. Duda,Carol F. Lippa,Elaine K. Perry,Dag Aarsland,Hiroyuki Arai,Clive Ballard,B. F. Boeve,David J. Burn,Durval C. Costa,T. Del Ser,Bruno Dubois,Douglas Galasko,Serge Gauthier,Christopher G. Goetz,Estrella Gómez-Tortosa,Glenda M. Halliday,L. A. Hansen,John Hardy,Takeshi Iwatsubo,Raj N. Kalaria,Daniel I. Kaufer,Rose Anne Kenny,Amos D. Korczyn,Kenji Kosaka,Virginia M.-Y. Lee,Andrew J. Lees,Irene Litvan,Elisabet Londos,Oscar L. Lopez,Satoshi Minoshima,Yoshikuni Mizuno,José Antonio Molina,Elizabeta B. Mukaetova-Ladinska,Florence Pasquier,Robert H. Perry,Jörg B. Schulz,John Q. Trojanowski,Masahito Yamada +45 more
TL;DR: The dementia with Lewy bodies (DLB) Consortium has revised criteria for the clinical and pathologic diagnosis of DLB incorporating new information about the core clinical features and suggesting improved methods to assess them as mentioned in this paper.
Journal ArticleDOI
α-Synuclein Locus Triplication Causes Parkinson's Disease
Andrew B. Singleton,Matthew J. Farrer,Joshua C. Johnson,Amanda Singleton,Stephen Hague,Jennifer M. Kachergus,Mary M. Hulihan,Terhi Peuralinna,Amalia Dutra,Robert L. Nussbaum,Sarah Lincoln,Anthony Crawley,Melissa Hanson,Demetrius M. Maraganore,Charles H. Adler,Mark R. Cookson,Manfred D. Muenter,Melisa J. Baptista,David Miller,J. Blancato,John Hardy,Katrina Gwinn-Hardy +21 more
TL;DR: In this article, the α-synuclein was identified as the major component of Lewy bodies, the pathological hallmark of Parkinson's disease, and of glial cell cytoplasmic inclusions.
Related Papers (5)
Mutation in the α-synuclein gene identified in families with Parkinson's disease
Mihael H. Polymeropoulos,Christian Lavedan,Elisabeth Leroy,Susan E. Ide,Anindya Dehejia,Amalia Dutra,Brian L. Pike,Holly Root,Jeffrey Rubenstein,Rebecca Boyer,Edward S. Stenroos,Settara C. Chandrasekharappa,Aglaia Athanassiadou,Theodore Papapetropoulos,William G. Johnson,Alice Lazzarini,Roger C. Duvoisin,Giuseppe Di Iorio,Lawrence I. Golbe,Robert L. Nussbaum +19 more