Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
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TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
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Journal ArticleDOI
DNA methylation-based age acceleration observed in IDH wild-type glioblastoma is associated with better outcome—including in elderly patients
Pierre Bady,Christine Marosi,Michael Weller,Bjørn Henning Grønberg,Henrik Schultz,Martin J.B. Taphoorn,J.M.M. Gijtenbeek,Martin J. van den Bent,Andreas von Deimling,Roger Stupp,Annika Malmström,Monika E. Hegi +11 more
TL;DR: In this article , the combined DNA methylome (450 k) of four IDH wild-type glioblastoma datasets, comprising two clinical trial cohorts, was interrogated for differences based on the patients' age, DNA methylation (DNAm) age acceleration (Horvath-clock) minus patient age), DNA-based tumor classification (Heidelberg), entropy, and functional methylation of DNA damage response (DDR) genes.
Dissertation
Síntesis química, actividad antitumoral modo de acción de la neurostatina y sus análogos sobre el crecimiento de gliomas
TL;DR: Results presented here indicate that semi-synthetic O-acetylated and O-butyrylated GD1b derivatives (neurostatin andO-But GD1B) are potent antitumoral compounds that block glioma cells growth, angiogenesis and invasion, also inducing its apoptosis, making them potential strategies for brain tumor treatment.
Journal ArticleDOI
Peritumoral edema status of glioblastoma identifies patients reaching long-term disease control with specific progression patterns after tumor resection and high-dose proton boost.
Hsiang-Kuang Tony Liang,Masashi Mizumoto,Eiichi Ishikawa,Masahide Matsuda,Keiichi Tanaka,Hidehiro Kohzuki,Haruko Numajiri,Yoshiko Oshiro,Toshiyuki Okumura,Akira Matsumura,Hideyuki Sakurai +10 more
TL;DR: In this article, peritumoral edema (PE) extent is associated with survival and progression pattern after tumor resection and radiotherapy (RT), and the correlation between PE extent and prognosis of glioblastoma after postoperative high-dose proton boost therapy stays unknown.
Genotype-phenotype studies in brain tumors
TL;DR: This data indicates that meningioma and glioma are the most common primary brain tumors, but their etiologies are largely unknown, and their intracranial location can lead to lethal consequences.
Dissertation
GSK-3 inhibitors in glioblastoma therapy: mechanisms of action
TL;DR: It is reported that GSK-3 inhibitors might have a valuable role in the treatment of GBM and BIO, CHIR99021, and LiCl all were shown to lessen cell migration and invasion in vitro in a range of assays and in all cell lines tested.
References
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