Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
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TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
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O 6 -methylguanine DNA methyltransferase gene promoter methylation in high-grade gliomas: A review of current status
TL;DR: It is indicated that MGMT promoter methylation has strong prognostic relevance even in anaplastic (grade III) gliomas, irrespective of therapy (chemotherapy or radiotherapy).
Journal ArticleDOI
Temozolomide may induce cell cycle arrest by interacting with URG4/URGCP in SH-SY5Y neuroblastoma cells
Veli Citisli,Yavuz Dodurga,Canan Eroğlu,Mücahit Seçme,Cigir Biray Avci,N. Lale Satiroglu-Tufan +5 more
TL;DR: It is thought that TMZ demonstrates anticarcinogenesis activity by affecting cell cycle arrest, apoptosis, invasion, and colony formation on SH-SY5Y cells.
Journal ArticleDOI
Towards personalized therapy for patients with glioblastoma
TL;DR: Recent studies that can provide personalized therapy for glioblastoma, based on molecular tumor profiling or patients’ physical status are reviewed, including studies for elderly patients and rational prognostic biomarkers.
Journal ArticleDOI
Patients receiving standard-dose temozolomide therapy are at risk of Pneumocystis carinii pneumonia.
Journal Article
Embryonic stem cell markers distinguishing cancer stem cells from normal human neuronal stem cell populations in malignant glioma patients.
TL;DR: The use of CD133 as a surrogate marker to identify TS cells within a GBM may not be clinically useful because glioblastomas contain both differentiated cancer cells and cancer stem cells in addition to normal adult neural stem cells that migrate into the tumor.
References
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