Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
Citations
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Cytomegalovirus associated colonic pseudotumor: a consequence of iatrogenic immunosuppression in a patient with primary brain tumor receiving radiation and temozolomide.
TL;DR: The case of a patient with primary brain tumor who developed cytomegalovirus associated colonic pseudotumor as an opportunistic infection while receiving chemotherapy with Temozolomide and radiation is reported.
Journal ArticleDOI
FKBP10 promotes proliferation of glioma cells via activating AKT-CREB-PCNA axis
Hong-Qing Cai,Min-Jie Zhang,Min-Jie Zhang,Zhi-Jian Cheng,Zhi-Jian Cheng,Jing Yu,Qing Yuan,Qing Yuan,Jin Zhang,Yan Cai,Li-Yan Yang,Yu Zhang,Jia-Jie Hao,Ming-Rong Wang,Jinghai Wan,Jinghai Wan +15 more
TL;DR: In this paper, the authors showed that FKBP10 is involved in proliferation of glioma cells by interacting with Hsp47 and activating AKT-CREB-PCNA signaling pathways.
Journal Article
Early post-operative MRI: correlation with progression-free survival and overall survival time in malignant gliomas.
Antonello Vidiri,Carmine M. Carapella,Andrea Pace,Alessandra Mirri,Alessandra Fabi,Mariantonia Carosi,Diana Giannarelli,Alfredo Pompili,Bruno Jandolo,Emanuele Occhipinti,S. Di Giovanni,M. Crecco +11 more
TL;DR: The study confirms that early-MR has to be considered an accurate technique for monitoring the extension of malignant glioma surgical resection and shows a good correlation between early- MR findings, PFS and ST.
Journal Article
Efficacy of Temozolomide Treatment in Patients with High-grade Glioma
Shinya Oshiro,Hitoshi Tsugu,Fuminari Komatsu,Tadahiro Ohmura,Mika Ohta,Seisaburou Sakamoto,Takeo Fukushima,Tooru Inoue +7 more
TL;DR: Assessing the true efficacy of TMZ will require a larger study with comparison of long-term outcomes between other agents or combined therapeutic modalities, as well as a study on Japanese populations.
Journal ArticleDOI
Phase I Trial of Radiosurgery Dose Escalation Plus Bevacizumab in Patients With Recurrent/Progressive Glioblastoma.
Mahmoud Abbassy,Mahmoud Abbassy,Symeon Missios,Gene H. Barnett,Cathy Brewer,David M. Peereboom,Manmeet Ahluwalia,Gennady Neyman,Samuel T. Chao,John H. Suh,Michael A. Vogelbaum +10 more
TL;DR: A single dose of bevacizumab prior to SRS permitted safe prescription dose escalation up to 22 Gy for rGBM, and further evaluation of the efficacy of SRS for r GBM should be performed in the setting of beVacIZumab treatment.
References
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