Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
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TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
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All in the head: obstacles for immune rejection of brain tumours.
TL;DR: It is suggested that immunotherapy for brain tumours cannot be rationally advanced as rapidly as that for tumours in other sites, and the idea that an automatic one-way progression exists from rodent models to the clinic should be abandoned.
Journal ArticleDOI
Tamoxifen alleviates irradiation-induced brain injury by attenuating microglial inflammatory response in vitro and in vivo
Jun-Li Liu,Dai-Shi Tian,Zaiwang Li,Wen-Sheng Qu,Yan Zhan,Minjie Xie,Zhiyuan Yu,Wei Wang,Gang Wu +8 more
TL;DR: Data support that tamoxifen can decrease the irradiation-induced brain damage via attenuating the microglial inflammatory response.
Journal ArticleDOI
Response Classification Based on a Minimal Model of Glioblastoma Growth Is Prognostic for Clinical Outcomes and Distinguishes Progression from Pseudoprogression
Maxwell Lewis Neal,Andrew D. Trister,Sunyoung Ahn,Anne Baldock,Carly Bridge,Laura Guyman,Jordan Lange,Rita Sodt,Tyler Cloke,Albert Lai,Timothy F. Cloughesy,Maciej M. Mrugala,Jason K. Rockhill,Russell C. Rockne,Kristin R. Swanson +14 more
TL;DR: A model-based metric of therapy response called Days Gained is developed that shows scores from a simple glioblastoma growth model computed at the time of the first postradiotherapy MRI scan are prognostic for time to tumor recurrence and overall patient survival.
Journal ArticleDOI
Different molecular patterns in glioblastoma multiforme subtypes upon recurrence
TL;DR: The results strongly suggest that recurrences of GBM may display two distinct pattern of accumulation of molecular alterations depending on the profile of the original tumor.
Journal ArticleDOI
Prevalence of symptoms in glioma patients throughout the disease trajectory: a systematic review
Margriet IJzerman-Korevaar,Tom J. Snijders,Alexander de Graeff,Saskia C.C.M. Teunissen,Filip de Vos +4 more
TL;DR: Eight out of ten of the most prevalent symptoms in glioma patients are related to the central nervous system and therefore specific for gliomas, and may aid in the development of specific PROMs for gluoma patients in different phases of the disease.
References
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