Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
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TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
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Book ChapterDOI
The Role of Laser-Induced Thermal Therapy in the Management of Malignant Gliomas
TL;DR: Several smaller studies now suggest that laser thermal ablation may result in improved survival in those who otherwise would be only eligible for biopsy at time of de novo diagnosis, given that complications following use of LITT can affect as many as one-third of treated patients.
Journal ArticleDOI
Rhabdoid Glioblastoma: Touch Imprint Cytology Clearly Demonstrates Globular Cytoplasmic Inclusions.
Yoshinari Yamamoto,Kazuto Yamazaki,Masatoshi Yamada,Yasuo Ishida,Takayuki Iwakami,Shinya Miyamoto,Katsumi Hoya +6 more
TL;DR: This case of rhabdoid glioblastoma (GBM) is presented, in which morphological features, especially globular cytoplasmic inclusions, were clearly demonstrated in intraoperative cytological specimens.
Journal ArticleDOI
Impact on Radiation Dose and Volume V57 Gy of the Brain on Recurrence and Survival of Patients with Glioblastoma Multiformae.
TL;DR: Iradiated volume with dose 57 Gy or more (V57 Gy) and ration between whole brain volume and 57 Gy had no impact on time to progression and survival of patients with glioblastoma.
Journal ArticleDOI
Adjuvant Temozolomide for the Treatment of Glioblastoma: A Meta-analysis of Randomized Controlled Studies.
TL;DR: In this article, a meta-analysis aimed to explore the influence of radiotherapy plus adjuvant temozolomide on the efficacy and safety for glioblastoma.
Journal ArticleDOI
Clinical observation in three-dimensional conformal radiotherapy (3D-CRT) with concurrent chemotherapy in treatment of postoperative cerebral gliomas
TL;DR: The 3D-CRT with concurrent chemotherapy can improve the survival of cerebral glioma with pathological grade III and Stratified analysis showed the patients with grade III gliomas of chemoradiotherapy group had better prognosis than ones of radiotherapy group.
References
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Recursive partitioning analysis of prognostic factors in three radiation therapy oncology group malignant glioma trials
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