Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
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TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
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Treatment of malignant gliomas: radiotherapy, chemotherapy and integration of new targeted agents.
TL;DR: A review of established and emerging prognostic factors and prognostic scores for glioblastomas can be found in this paper, where the authors discuss their limitations and potential influence on future therapeutic efforts.
Journal ArticleDOI
18F-FCho PET and MRI for the prediction of response in glioblastoma patients according to the RANO criteria.
Julie Bolcaen,Marjan Acou,Tom Boterberg,Christian Vanhove,Filip De Vos,Caroline Van den Broecke,Roel Van Holen,Karel Deblaere,Ingeborg Goethals +8 more
TL;DR: The data indicate that both 18F-FCho PET and contrast-enhanced T1-weighted MRI can predict response early in GB patients treated with RT and temozolomide.
Journal ArticleDOI
New developments in the treatment of malignant gliomas.
TL;DR: Anasplastic oligodendroglial tumors display a better prognosis and are more chemosensitive than glioblastomas; the discovery of molecular factors of prognostic significance, such as 1p/19q codeletion, will lead to different treatment strategies for different subgroups of patients.
Journal ArticleDOI
Incidence of Pneumocystis jirovecii pneumonia after temozolomide for CNS malignancies without prophylaxis
Alexander J. Neuwelt,Tam Nguyen,Rongwei Fu,Joseph S. Bubalo,Rose Marie Tyson,Cynthia Lacy,Seymur Gahramanov,Morad Nasseri,Penelope D. Barnes,Edward A. Neuwelt,Edward A. Neuwelt +10 more
TL;DR: There was a <1% rate of PJP for brain tumor patients treated with temozolomide until progression without PJP prophylaxis for newly diagnosed glioblastoma multiforme patients, according to a retrospective chart review.
Journal ArticleDOI
Prognostic Value of MTV, SUVmax and the T/N Ratio of PET/CT in Patients with Glioma: A Systematic Review and Meta-Analysis.
TL;DR: PET/CT parameters T/N ratio may be a significant prognostic factor in patients with glioma and PET/CT scan could be a promising technique to provide prognostic information for these patients.
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