Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
Citations
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Journal ArticleDOI
New Treatments for Malignant Gliomas: Careful Evaluation and Cautious Optimism Required
TL;DR: The study examines the potential benefit of adding chloroquine to a treatment regimen consisting of radiation plus carmustine, a nitrosourea that has been used to treat brain tumors, and examines the small number of patients enrolled in Sotelo and colleagues' trial, which raises concern that the chlorquine and placebo groups differ in the frequency of prognostic factors.
Journal ArticleDOI
Classification and management of anaplastic gliomas.
Wolfgang Wick,Michael Weller +1 more
TL;DR: Anaplastic gliomas are an important group of brain tumors to develop future molecularly targeted therapies and should therefore be in the main focus of academic and industrial drug development, which aims at efficacy and avoiding long-term side effects.
Journal ArticleDOI
Open-label simultaneous radio-chemotherapy of glioblastoma multiforme with topotecan in adults.
Markus W. Gross,Riglef Altscher,Michael Brandtner,Harald Haeusser-Mischlich,Ion C. Chiricuta,Alessandra D. Siegmann,Rita Engenhart-Cabillic +6 more
TL;DR: This multimodal approach is well tolerated, and quality of life remains preserved, and the relatively long median survival time is promising but a further randomised double blind placebo controlled parallel designed clinical trial should be performed to confirm these results.
Journal ArticleDOI
In vivo DCE-MRI for the discrimination between glioblastoma and radiation necrosis in rats
Julie Bolcaen,Benedicte Descamps,Marjan Acou,Karel Deblaere,Caroline Van den Broecke,Tom Boterberg,Christian Vanhove,Ingeborg Goethals +7 more
TL;DR: In a rat model of GB and RN, wash-in rate, washing-out rate, and the time to peak extracted from DCE-MRI time series data may be useful to discriminate glioblastoma from radiation necrosis in rats.
Journal ArticleDOI
Prognostic value of test(s) for O6‐methylguanine–DNA methyltransferase (MGMT) promoter methylation for predicting overall survival in people with glioblastoma treated with temozolomide
Alexandra McAleenan,Claire Kelly,Francesca Spiga,Ashleigh Kernohan,Hung-Yuan Cheng,Sarah Dawson,Sarah Dawson,Lena Schmidt,Tomas Robinson,Sebastian Brandner,Sebastian Brandner,Claire Faulkner,Christopher Wragg,Sarah Jefferies,Amy E Howell,Luke Vale,Julian P T Higgins,Julian P T Higgins,Kathreena M Kurian +18 more
TL;DR: In this paper, the authors compared three methods of measuring MGMT promoter methylation: immunohistochemistry (IHC), methylation-specific polymerase chain reaction (MSP) and pyrosequencing (PSQ), with ratios of hazard ratios (RHR).
References
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