Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
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Diagnostic utility of restriction spectrum imaging (RSI) in glioblastoma patients after concurrent radiation-temozolomide treatment: A pilot study.
Usman A. Khan,Robert C. Rennert,Nathan S. White,Hauke Bartsch,Nikdokht Farid,Anders M. Dale,Clark C. Chen +6 more
TL;DR: RSI should be considered in the evaluation of treatment effects versus tumor recurrence in glioblastoma patients after RT-TMZ therapy, according to the sensitivity, specificity, positive and negative predictive values.
Journal ArticleDOI
Hepatitis B virus reactivation associated with temozolomide for malignant glioma: a case report and recommendation for prophylaxis
Yasunori Fujimoto,Naoya Hashimoto,Manabu Kinoshita,Yuko Miyazaki,Satoshi Tanaka,Takayuki Yakushijin,Tetsuo Takehara,Naoki Kagawa,Toshiki Yoshimine +8 more
TL;DR: A rare case of severe HBV reactivation during postoperative radiotherapy with concomitant and adjuvant temozolomide for malignant glioma in a 49-year-old Japanese woman and the utility of HBV screening and antiviral prophylaxis before administration of TMZ is suggested.
Journal Article
Management of patients with newly diagnosed malignant primary brain tumors with a focus on the evolving role of temozolomide.
TL;DR: The prognosis for patients with newly diagnosed malignant gliomas remains poor and advances in neurosurgical techniques have improved the safety of tumor resection and most patients undergo the maximal safe surgical debulking of tumor.
Journal ArticleDOI
A phase II single-arm study of irinotecan in combination with temozolomide (TEMIRI) in children with newly diagnosed high grade glioma: a joint ITCC and SIOPE-brain tumour study.
Darren Hargrave,Birgit Geoerger,Didier Frappaz,Torsten Pietsch,Lyle Gesner,Laura Cisar,Aurora Breazna,Andrew Dorman,Ofelia Cruz-Martinez,José Luis Fuster,Xavier Rialland,Celine Icher,P. Leblond,David M. Ashley,Giorgio Perilongo,Martin Elliott,Martin English,Niels Clausen,Jacques Grill +18 more
TL;DR: Iinotecan plus temozolomide, although well tolerated did not improve outcome over historical controls in this setting, and overall survival is reported.
Journal Article
Valproic acid related idiosyncratic drug induced hepatotoxicity in a glioblastoma patient treated with temozolomide
TL;DR: A 48-year-old glioblastoma patient who developed acute cholestatic hepatitis with hepatic failure during adjuvant treatment with temozolomide and the integrin inhibitor cilengitide is reported.
References
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