Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
Citations
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Journal ArticleDOI
Chemoradiotherapy in high-grade gliomas
Pietro Corsa,Salvatore Parisi,Arcangela Raguso,Michele Troiano,Antonio Perrone,Sabrina Cossa,Tindara Munafò,Michele Piombino,Girolamo Spagnoletti,Francesco Borgia +9 more
TL;DR: The authors found that age is a significant factor for survival, which is consistent with the literature, but some of the patients received a lower dose than the effective dose due to their poor performance status, and the authors should have stressed this.
Book ChapterDOI
Overview of pathology and treatment of primary brain tumours
TL;DR: In this article , the authors considered adjunctive treatment for all malignant primary brain tumours (PBTs) and for selected low-grade gliomas, and the standard regimen consists of 5000-6000 cGy administered in 180-200 cGy daily fractions over 5-7 weeks.
Journal Article
Plasma cell neoplasm in conjunction with glioblastoma of the conus medullaris.
TL;DR: A plasma cell neoplasm is reported in conjunction with a glioblastoma multiforme (GBM) of the conus medullaris in a 42-year-old man and is related to other plasma cell and hematopoietic diseases such as Waldenstrom's macroglobulinemia and myeloid sarcomas.
Journal ArticleDOI
Nuevos quimioterápicos en Neurooncología
Carmen Balaña Quintero,Rafael Rosell Costa,Rosa Ballester Alabau,Antonio Arellano Tolivar,Beatriz Cirauqui Cirauqui,Teresa Morán Bueno +5 more
TL;DR: Two metanalysis support the benefit of chemotherapy in this subset of patients with glioma patients, and dispose now of new drugs that cross blood brain barrier without adding neurological toxicity and with known activity over gliomas and brain metastasis.
Journal ArticleDOI
The STAT3-Regulated Autophagy Pathway in Glioblastoma
TL;DR: The role of the STAT3 transcription factor in autophagy is discussed in this paper , which provides the basis for future research aimed at targeting the autophag-dependent pathway to overcome the inherent therapeutic resistance of GBM in general and to specifically target the highly therapy-resistant GSC population through autophathy regulation.
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