Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
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TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
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18F-fluoromethylcholine (FCho), 18F-fluoroethyltyrosine (FET), and 18F-fluorodeoxyglucose (FDG) for the discrimination between high-grade glioma and radiation necrosis in rats: A PET study
Julie Bolcaen,Benedicte Descamps,Karel Deblaere,Tom Boterberg,Filip De Vos Pharm,Jean-Pierre Kalala,Caroline Van den Broecke,Elke Decrock,Luc Leybaert,Christian Vanhove,Ingeborg Goethals +10 more
TL;DR: The results suggest that (delayed) (18)F-FDG and (18]F-FET PET can be used to discriminate GB (recurrence) from RN, and delayed PET seems particularly useful.
Journal ArticleDOI
Molecular imaging of brain tumors with 18F-DOPA PET and PET/CT.
Ferdinando Calabria,Agostino Chiaravalloti,Barbara Di Pietro,Cristina Grasso,Orazio Schillaci +4 more
TL;DR: PET and PET/CT with 18F-DOPA are useful in diagnosing primary brain tumors and should be recommended in the diagnosis of relapse of disease after surgical treatment and/or radiotherapy.
Journal ArticleDOI
Biological equivalent dose studies for dose escalation in the stereotactic synchrotron radiation therapy clinical trials.
Yolanda Prezado,G. Fois,M. Edouard,Christian Nemoz,Michel Renier,Herwig Requardt,François Estève,Jean-François Adam,Hélène Elleaume,Alberto Bravin +9 more
TL;DR: To estimate the possible risks, the doses received by the tumor and healthy tissues in the future clinical conditions have been calculated by using Monte Carlo simulations (PENELOPE code) and a scheme for the dose escalation in the various phases of the clinical trials has been proposed.
Journal ArticleDOI
One decade of glioblastoma multiforme surgery in 342 elderly patients: what have we learned?
Dieter Henrik Heiland,Gerrit Haaker,Ralf Watzlawick,Daniel Delev,Waseem Masalha,Pamela Franco,Marcia Machein,Ori Staszewski,Oliver Oelhke,Nils H. Nicolay,Oliver Schnell +10 more
TL;DR: GTR and adjuvant combined RCT provides benefits for overall survival in elderly patients and therapy decision should be made in regard to preoperative functional status instead of biological age.
Journal ArticleDOI
ALA-PpIX mediated photodynamic therapy of malignant gliomas augmented by hypothermia
Carl Fisher,Carolyn Niu,Warren D. Foltz,Yonghong Chen,Elena Sidorova-Darmos,James H. Eubanks,James H. Eubanks,Lothar Lilge,Lothar Lilge +8 more
TL;DR: A role for hypothermia in photonics-based surgical techniques is suggested, and that a hypothermic intervention could lead to considerable patient outcome improvements.
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