Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
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TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
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Current and future strategies for the treatment of malignant brain tumors
Maria G. Castro,Rachel L. Cowen,I.K Williamson,I.K Williamson,Andréia Márcia Santos de Souza David,Maximiliano J. Jiménez-Dalmaroni,Maximiliano J. Jiménez-Dalmaroni,Xiangpeng Yuan,Xiangpeng Yuan,A Bigliari,Judith C. Williams,Jinwei Hu,Jinwei Hu,Pedro R. Lowenstein,Pedro R. Lowenstein,Pedro R. Lowenstein +15 more
TL;DR: This review will focus on the classical ways in which GB is currently being treated, and will introduce a novel therapeutic modality, i.e., gene therapy, which it is believed will be used in combination with classical treatment strategies to prolong the life-span of patients and to ultimately be able to control and/or cure these brain tumors.
Journal ArticleDOI
Optimal role of temozolomide in the treatment of malignant gliomas.
TL;DR: Molecular studies suggest a strong predictive role of the DNA repair enzyme O6-methyl-guanine-DNA- methyl-transferase (MGMT) and outcome of TMZbased chemotherapy and this review summarizes the current knowledge, highlights approved and nonapproved indications, and describes molecular studies that may allow us to identify the patients most likely to benefit from this treatment.
Journal ArticleDOI
P450 enzyme inducing and non-enzyme inducing antiepileptics in glioblastoma patients treated with standard chemotherapy.
Stefan Oberndorfer,Maria Piribauer,Christine Marosi,Heinz Lahrmann,Peter Hitzenberger,Wolfgang Grisold +5 more
TL;DR: Results indicate that AED influence the pharmacokinetics of chemotherapeutic drugs in patients with GBM, and valproic acid might be responsible for increasing haematotoxicity.
Journal ArticleDOI
Ionizing radiation induces astrocyte gliosis through microglia activation.
So-Young Hwang,Jae Seob Jung,Tae Hyun Kim,Soo Jeong Lim,Eok Soo Oh,Joo-Young Kim,Kyung Ae Ji,Eun Hye Joe,Kwan Ho Cho,Inn-Oc Han +9 more
TL;DR: The data suggest that radiation-induced microglial activation and resultant production of PGE2 seems to be associated with an underlying cause of inflammatory complications associated with radiation therapy for malignant gliomas.
Journal ArticleDOI
A microarray-based DNA methylation study of glioblastoma multiforme
Ramon Martinez,José I. Martín-Subero,Veit Rohde,Matthias Kirsch,Miguel Alaminos,Agustín F. Fernández,Santiago Ropero,Gabriele Schackert,Manel Esteller +8 more
TL;DR: The DNA methylation level of 1,505 CpG dinucleotides (807 genes) in 87 consecutive GBMs using universal BeadArrays is quantified and the group of genes hypermethylated in GBM was highly enriched (41%, P).
References
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