Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
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TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
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Journal ArticleDOI
Medical management of brain tumors and the sequelae of treatment
TL;DR: Major aspects of supportive care for patients with malignant brain tumors are discussed, with particular attention to management of seizures, venous thromboembolism, corticosteroids and their complications, chemotherapy including bevacizumab, and fatigue, mood, and cognitive dysfunction.
Journal ArticleDOI
Phase II trial of irinotecan plus celecoxib in adults with recurrent malignant glioma.
David A. Reardon,Jennifer A. Quinn,James J. Vredenburgh,Jeremy N. Rich,Sridharan Gururangan,Michael A. Badruddoja,James E. Herndon,Jeannette M. Dowell,Allan H. Friedman,Henry S. Friedman +9 more
TL;DR: A Phase II trial of irinotecan (CPT‐11), a topoisomerase I inhibitor active against malignant glioma (MG), with celecoxib, a selective COX‐2 inhibitor, among MG patients with recurrent disease is reported.
Journal ArticleDOI
Recent developments in the use of chemotherapy in brain tumours
TL;DR: For example, the authors showed that combining radiotherapy with adjuvant nitrosourea-based chemotherapy does not improve overall survival in newly diagnosed anaplastic oligodendroglioma, even in the subset of 1p/19q loss tumours.
Journal ArticleDOI
The role of radio- and chemotherapy in glioblastoma.
Roger Stupp,Damien C. Weber +1 more
TL;DR: A statistically significant increase of survival for patients treated with 3D planning when compared to those treated with 2D planning is reported, and an improved survival with an applied radiation dose of ≥ 56 Gy is reported.
Journal ArticleDOI
A phase II study of temozolomide in patients with newly diagnosed supratentorial malignant glioma before radiation therapy
Mark R. Gilbert,Henry S. Friedman,John F. Kuttesch,Michael D. Prados,Jeffrey J. Olson,Gregory H. Reaman,Sara L. Zaknoen +6 more
TL;DR: A multicenter phase II trial to determine the efficacy and safety of temozolomide before radiotherapy in patients with newly diagnosed GBM and AA found this pre-irradiation treatment approach appears promising, but will require additional evaluation in comparative studies.
References
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Walker,Eben Alexander,William E. Hunt,MacCarty Cs,Mahaley Ms,John Mealey,Norrell Ha,Owens G,Joseph Ransohoff,Charles B. Wilson,Gehan Ea,Strike Ta +11 more
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