Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
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TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
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Journal ArticleDOI
Phase II trial of temozolomide (TMZ) plus irinotecan (CPT-11) in adults with newly diagnosed glioblastoma multiforme before radiotherapy.
Jennifer A. Quinn,Sara Xiaoyin Jiang,David A. Reardon,Annick Desjardins,James J. Vredenburgh,Allan H. Friedman,John H. Sampson,Roger E. McLendon,James E. Herndon,Henry S. Friedman +9 more
TL;DR: Although TMZ plus CPT-11 is at least comparable in efficacy to TMZ alone, this combination appears more toxic and poorly tolerated.
Journal ArticleDOI
Concurrent radiotherapy with temozolomide followed by adjuvant temozolomide and cis-retinoic acid in children with diffuse intrinsic pontine glioma
Nongnuch Sirachainan,Samart Pakakasama,Anannit Visudithbhan,Surang Chiamchanya,Lojana Tuntiyatorn,Mantana Dhanachai,Jiraporn Laothamatas,Suradej Hongeng +7 more
TL;DR: It is concluded that the regimen of concurrent radiotherapy with temozolomide (TMZ) and TMZ should be considered for further investigation in a larger series of patients.
Journal ArticleDOI
Temozolomide in combination with BCNU before and after radiotherapy in patients with inoperable newly diagnosed glioblastoma multiforme
Maryline Barrie,C. Couprie,H. Dufour,Dominique Figarella-Branger,Xavier Muracciole,Khê Hoang-Xuan,Diane Braguer,Pierre-Marie Martin,Jean-Claude Peragut,François Grisoli,Olivier Chinot +10 more
TL;DR: The combination of BCNU plus temozolomide as neo-adjuvant therapy in inoperable GBM exhibited promising activity with a good safety profile and warrants further evaluation.
Journal ArticleDOI
Apurinic endonuclease activity in adult gliomas and time to tumor progression after alkylating agent-based chemotherapy and after radiotherapy.
Michael S. Bobola,Mary J. Emond,A. Blank,Elizabeth H. Meade,Douglas D. Kolstoe,Mitchel S. Berger,Robert C. Rostomily,Daniel L. Silbergeld,Alexander M. Spence,John R. Silber +9 more
TL;DR: The data suggest that Ap endo activity mediates resistance to alkylating agents and radiation and may be a useful predictor of progression after adjuvant therapy in a subset of gliomas.
Journal ArticleDOI
[F-18]-fluorodeoxyglucose positron emission tomography for targeting radiation dose escalation for patients with glioblastoma multiforme: clinical outcomes and patterns of failure.
James G. Douglas,Keith J. Stelzer,David A. Mankoff,Kevin S. Tralins,Kenneth A. Krohn,Mark Muzi,Daniel L. Silbergeld,Robert C. Rostomily,Jeffrey Scharnhorst,Alexander M. Spence +9 more
TL;DR: The feasibility of integrating PET metabolic imaging into radiotherapy treatment planning is established, and radiation dose escalation to 79.4 Gy based on FDG-PET imaging demonstrated no improvement in OS or PFS.
References
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Walter J. Curran,Charles B. Scott,John Horton,James S. Nelson,Alan S. Weinstein,A. J. Fischbach,C. H. Chang,Marvin Rotman,Sucha O. Asbell,Robert E. Krisch,D. F. Nelson +10 more
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