Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
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TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
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Overall survival time prediction for high-grade glioma patients based on large-scale brain functional networks
Luyan Liu,Han Zhang,Jinsong Wu,Zhengda Yu,Xiaobo Chen,Islem Rekik,Islem Rekik,Qian Wang,Junfeng Lu,Dinggang Shen,Dinggang Shen +10 more
TL;DR: This paper proposes a novel concept, namely brain connectomics-based OS prediction based on presurgical resting-state functional MRI and the non-local, large-scale brain functional networks where the global and systemic prognostic features rather than the local lesion appearance are used to predict OS.
Journal ArticleDOI
Wilms tumor 1 peptide vaccination combined with temozolomide against newly diagnosed glioblastoma: safety and impact on immunological response.
Naoya Hashimoto,Akihiro Tsuboi,Naoki Kagawa,Yasuyoshi Chiba,Shuichi Izumoto,Manabu Kinoshita,Noriyuki Kijima,Yoshihiro Oka,Soyoko Morimoto,Hiroko Nakajima,Satoshi Morita,Junichi Sakamoto,Sumiyuki Nishida,Naoki Hosen,Yusuke Oji,Norio Arita,Toshiki Yoshimine,Haruo Sugiyama +17 more
TL;DR: The safety profile of the combined Wilms tumor 1 peptide vaccination and temozolomide therapy approach for treating glioblastoma was confirmed and patients showed good tolerability during the observation period.
Journal ArticleDOI
Targeted Radiolabeled Compounds in Glioma Therapy.
TL;DR: The consistent overexpression of neurokinin type 1 receptors in gliomas WHO grades II-IV has been used to develop a therapeutic substance P-based targeting system and the results compare favorably with standard therapy.
Journal ArticleDOI
Recent Advances in Combined Modality Therapy
TL;DR: This review highlights the recent clinical data in support of newer generation cytotoxic chemotherapies and systemic targeted agents in combination with radiation therapy.
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Combined radio- and chemotherapy of brain tumours in adult patients.
TL;DR: A review was carried out of recent studies examining surgery, radiotherapy and chemotherapy in high-grade glioma, medulloblastoma and primary central nervous system lymphoma regarding combined radio- and chemotherapy for adult patients with brain tumours.
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