Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
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TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
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Journal ArticleDOI
Phase II Study of Temozolomide and Concomitant Whole-Brain Radiotherapy in Patients with Brain Metastases from Solid Tumors
John Kouvaris,Anthi Miliadou,Vassilis Kouloulias,Dimitrios Kolokouris,Myrsini Balafouta,Xenofon N. Papacharalampous,Lambros Vlahos +6 more
TL;DR: WBI combined with TMZ as concomitant and adjuvant treatment is effective in treating brain metastases, with acceptable mild side effects.
Journal ArticleDOI
Combination of intracranial temozolomide with intracranial carmustine improves survival when compared with either treatment alone in a rodent glioma model
Violette Recinos,Betty Tyler,Kimon Bekelis,Sarah B. Sunshine,Ananth K. Vellimana,Khan W. Li,Henry Brem +6 more
TL;DR: The survival of tumor-bearing animals in the 9L and F98 glioma models was improved with the local delivery of BCNU and TMZ combined with XRT when compared with either treatment alone or oral TMZ, localBCNU, and XRT.
Journal ArticleDOI
Interleukin-13 receptor alpha 2 cooperates with EGFRvIII signaling to promote glioblastoma multiforme
Jennifer P. Newman,Grace Y. Wang,Kazuhiko Arima,Shou P. Guan,Michael R. Waters,Webster K. Cavenee,Edward Pan,Edita Aliwarga,Siao T. Chong,Catherine Y. L. Kok,Berwini Endaya,Amyn A. Habib,Tomohisa Horibe,Wai Hoe Ng,Ivy A.W. Ho,Kam M. Hui,Tomasz Kordula,Paula Y.P. Lam +17 more
TL;DR: It is reported that IL-13Rα2 alone induces invasiveness of human GBM cells without affecting their proliferation, and it is suggested that targeting both receptors with STAT3 signaling inhibitor might be a therapeutic approach for the treatment of GBM.
Journal ArticleDOI
A clinicopathological and molecular analysis of glioblastoma multiforme with long-term survival
Prasenjit Das,Tarun Puri,Prerana Jha,Pankaj Pathak,Nikhil P. Joshi,Vaishali Suri,Mehar Chand Sharma,Bhawani Shankar Sharma,Ashok Kumar Mahapatra,Ashish Suri,Chitra Sarkar +10 more
TL;DR: A relatively young age of onset, with a high MGMT promoter methylation and PTEN protein expression were favorable factors for long-term survival, and the presence of EGFR amplification indicates that more than a single factor determines survival in GBM.
Journal Article
The role of surgery in high-grade glioma--is surgical resection justified? A review of the current knowledge.
TL;DR: There is a lack of evidence to support a survival benefit with aggressive gliomas resection, but this should not detract patients from undergoing surgery as there are many other clinical benefits of glioma excision.
References
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Evaluation of BCNU and/or radiotherapy in the treatment of anaplastic gliomas: A cooperative clinical trial
Walker,Eben Alexander,William E. Hunt,MacCarty Cs,Mahaley Ms,John Mealey,Norrell Ha,Owens G,Joseph Ransohoff,Charles B. Wilson,Gehan Ea,Strike Ta +11 more
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Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas
Henry Brem,Steven Piantadosi,Steven Piantadosi,Peter C. Burger,Michael D. Walker,Robert G. Selker,N. A. Vick,K Black,Michael B. Sisti,Steven Brem,G Mohr,P Muller,R Morawetz,S.C Schold +13 more
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Recursive partitioning analysis of prognostic factors in three radiation therapy oncology group malignant glioma trials
Walter J. Curran,Charles B. Scott,John Horton,James S. Nelson,Alan S. Weinstein,A. J. Fischbach,C. H. Chang,Marvin Rotman,Sucha O. Asbell,Robert E. Krisch,D. F. Nelson +10 more
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