Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
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TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
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Journal ArticleDOI
Gene Expression and Methylation Analyses Suggest DCTD as a Prognostic Factor in Malignant Glioma.
Huimin Hu,Zheng Wang,Mingyang Li,Fan Zeng,Kuanyu Wang,Ruoyu Huang,Haoyuan Wang,Fan Yang,Tingyu Liang,Hua Huang,Tao Jiang +10 more
TL;DR: The gene coding a key enzyme in genetic material synthesis, dCMP deaminase (DCTD), was found to be significantly correlated with overall survival and high level of DCTD mRNA indicated shorter survival of the patients with malignant glioma in different databases.
Journal ArticleDOI
Bioprocessing of Human Glioblastoma Brain Cancer Tissue
Krishna M. Panchalingam,Wendy J. Paramchuk,Chun-Yi Katherine Chiang,Nameeta Shah,Anup Madan,Leroy Hood,Greg Foltz,Leo A. Behie +7 more
TL;DR: Bioreactor protocols for the suspension culture of an aggressive and deadly type of brain cancer called glioblastoma multiforme and genomic characterization indicated that a very small number of key genes were differentially expressed in the bioreactor-expanded GBM-derived cells, thereby conserving the basic nature of the brain cancer tissue in the cell expansion process.
Radiation therapy oncology group rtog 0825 phase iii double-blind placebo-controlled trial of conventional concurrent chemoradiation and adjuvant temozolomide plus bevacizumab versus conventional concurrent chemoradiation and adjuvant temozolomide in patients with newly diagnosed glioblastoma
Holcombe Blvd,Minesh P. Mehta,Kenneth A. Aldape,Howard Colman,Terri Armstrong,Jeffrey S. Wefel +5 more
TL;DR: Neurosurgery Michael A. Vogelbaum, MD, PhD Brain Tumor Institute Department of Neurosurgery/ND40 Cleveland Clinic Foundation 9500 Euclid Avenue Cleveland, OH 44195 216-444-8564/Fax 216- 444-2682 vogelbm@ccf.org
Journal ArticleDOI
Temozolomide induced bone marrow Suppression–A single institution outcome analysis and review of the literature
TL;DR: Combined PET and biopsy evidence of marrow involvement improves prognostic prediction in diffuse large B-cell lymphoma and PET-CT staging of DLBCL accurately identifies and provides new insight into the clinical significance of bone marrow involvement.
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The role of cytotoxic drugs in the treatment of central nervous system gliomas.
Bart Neyns,Miguel D'haeseleer,Anne Rogiers,Joy Van de Cauter,C. Chaskis,Alex Michotte,Herwig Strik +6 more
TL;DR: Anti-angiogenic agents and targeted receptor tyrosine kinase inhibitors are new pharmacological classes with activity against malignant gliomas, and combinations of these new agents with classical cytotoxic agents in first and in second line have recently been initiated.
References
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