Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
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TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
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Role of stereotactic radiosurgery and fractionated stereotactic radiotherapy for the treatment of recurrent glioblastoma multiforme
Pantaleo Romanelli,Alfredo Conti,Antonio Pontoriero,Giuseppe Ricciardi,Francesco Tomasello,Costantino De Renzis,Gualtiero Innocenzi,Vincenzo Esposito,Giampaolo Cantore +8 more
TL;DR: The authors reviewed the current applications and efficacy of SRS and fSRT in the treatment of GBM, highlighting the value of these therapies for recurrent focal disease.
Journal ArticleDOI
Second-line chemotherapy with irinotecan plus carmustine in glioblastoma recurrent or progressive after first-line temozolomide chemotherapy: a phase II study of the Gruppo Italiano Cooperativo di Neuro-Oncologia (GICNO).
Alba A. Brandes,Alicia Tosoni,Umberto Basso,Michele Reni,F. Valduga,S. Monfardini,P. Amista,Linda Nicolardi,Guido Sotti,M. Ermani +9 more
TL;DR: The BCNU plus irinotecan regimen seems active and non-cross-resistant in patients with GBM with recurrence after temozolomide-based chemotherapy.
Journal ArticleDOI
Multi-Channel 3D Deep Feature Learning for Survival Time Prediction of Brain Tumor Patients Using Multi-Modal Neuroimages
Dong Nie,Junfeng Lu,Han Zhang,Ehsan Adeli,Jun Wang,Zhengda Yu,Luyan Liu,Qian Wang,Jinsong Wu,Dinggang Shen,Dinggang Shen +10 more
TL;DR: This study proposes a multi-channel architecture of 3D convolutional neural networks (CNNs) for deep learning upon those metric maps, from which high-level predictive features are extracted for each individual patch of these maps.
Journal ArticleDOI
Adjuvant Immunotherapy with Whole-Cell Lysate Dendritic Cells Vaccine for Glioblastoma Multiforme: A Phase II Clinical Trial.
Der Yang Cho,Wen Kuang Yang,Han Chung Lee,Den Mei Hsu,Hung Lin Lin,Shinn Zong Lin,Chun Chung Chen,Horng-Jyh Harn,Chun Lin Liu,Wen-Yuan Lee,Li Hui Ho +10 more
TL;DR: Adjuvant immunotherapy with whole-cell lysate dendritic cell vaccine may improve short-term survival and its long-term effectiveness is worthy of further investigation.
Journal ArticleDOI
Volume of residual disease as a predictor of outcome in adult patients with recurrent supratentorial glioblastomas multiforme who are undergoing chemotherapy.
TL;DR: It is indicated that patients with recurrent GBMs who start chemotherapy with a smaller volume of residual disease at the start of treatment may have a more favorable response to chemotherapy and a more unfavorable outcome.
References
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