Journal ArticleDOI
Promising Survival for Patients With Newly Diagnosed Glioblastoma Multiforme Treated With Concomitant Radiation Plus Temozolomide Followed by Adjuvant Temozolomide
Roger Stupp,Pierre Yves Dietrich,Sandrine Ostermann Kraljevic,Alessia Pica,Ivan Maillard,Phillipe Maeder,Reto Meuli,Robert C. Janzer,Gianpaolo Pizzolato,Raymond Miralbell,F. Porchet,Luca Regli,Nicolas de Tribolet,René O. Mirimanoff,Serge Leyvraz +14 more
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TLDR
This regimen of concomitant chemoradiotherapy followed by adjuvant chemotherapy may prolong the survival of patients with glioblastoma.Abstract:
PURPOSE: Temozolomide is a novel oral alkylating agent with demonstrated efficacy as second-line therapy for patients with recurrent anaplastic astrocytoma and glioblastoma multiforme (GBM). This phase II study was performed to determine the safety, tolerability, and efficacy of concomitant radiation plus temozolomide therapy followed by adjuvant temozolomide therapy in patients with newly diagnosed GBM. PATIENTS AND METHODS: Sixty-four patients were enrolled onto this open-label, phase II trial. Temozolomide (75 mg/m2/d × 7 d/wk for 6 weeks) was administered orally concomitant with fractionated radiotherapy (60 Gy total dose: 2 Gy × 5 d/wk for 6 weeks) followed by temozolomide monotherapy (200 mg/m2/d × 5 days, every 28 days for six cycles). The primary end points were safety and tolerability, and the secondary end point was overall survival. RESULTS: Concomitant radiation plus temozolomide therapy was safe and well tolerated. Nonhematologic toxicities were rare and mild to moderate in severity. During t...read more
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The Wnt inhibitory factor 1 (WIF1) is targeted in glioblastoma and has a tumor suppressing function potentially by induction of senescence
Wanyu L. Lambiv,Irene Vassallo,Mauro Delorenzi,Tal Shay,Annie-Claire Diserens,Anjan Misra,Burt G. Feuerstein,Anastasia Murat,Eugenia Migliavacca,Marie-France Hamou,Davide Sciuscio,Raphaël Burger,Eytan Domany,Roger Stupp,Monika E. Hegi +14 more
TL;DR: Evidence is provided that WIF1 has tumor suppressing properties that may render glioblastomas sensitive to inhibitors of Wnt signaling, potentially by diverting the tumor cells into a senescence-like state.
Journal Article
Radiotherapy and radiosensitizers in the treatment of glioblastoma multiforme.
TL;DR: Novel imaging techniques are being explored in an effort to improve local control of tumor and limit toxicity to normal brain tissue, and novel means of delivering RT, including radioimmunotherapy, have demonstrated efficacy with acceptable toxicity.
Journal ArticleDOI
Role of temozolomide after radiotherapy for newly diagnosed diffuse brainstem glioma in children: results of a multiinstitutional study (SJHG-98).
Alberto Broniscer,Lisa C. Iacono,Murali Chintagumpala,Maryam Fouladi,Dana Wallace,Daniel C. Bowers,Clinton F. Stewart,Matthew J. Krasin,Amar Gajjar +8 more
TL;DR: The efficacy of temozolomide treatment after radiotherapy (RT) in children with newly diagnosed diffuse brainstem glioma was tested in this setting.
Journal ArticleDOI
The use of hypofractionated intensity-modulated irradiation in the treatment of glioblastoma multiforme: preliminary results of a prospective trial.
Khalil Sultanem,Horacio Patrocinio,C. Lambert,R Corns,Richard Leblanc,William Parker,George Shenouda,Luis Souhami +7 more
TL;DR: This hypofractionated accelerated irradiation schedule using forward planning (step-and-shoot) hyp ofractionated, intensity-modulated accelerated radiotherapy is feasible and seems to be a safe treatment for patients with GBM.
Journal ArticleDOI
Reoperation for recurrent high-grade glioma: a current perspective of the literature.
TL;DR: Mounting evidence suggests a survival benefit in patients receiving a reoperation at the time of high-grade glioma recurrence, even in patients with subtotal resection at initial operation.
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