Journal ArticleDOI
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
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TLDR
The discovery of caspase-11/4/5 function in sensing intracellular lipopolysaccharide expands the spectrum of pyroptosis mediators and also reveals that pyroPTosis is not cell type specific.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2017-04-01. It has received 1611 citations till now. The article focuses on the topics: Pyroptosis & Pore forming protein.read more
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Dissertation
Etude de la modulation des cellules myeloïdes murines au cours de l'endotoxémie
TL;DR: La septicemie est un syndrome complexe au cours duquel une infection systemique conduit a une inflammation exacerbee and une immunosuppression pouvant mener au developpement d’infections secondaires, nous avons observe that le LPS permet l’induction d”une monopoiese active dans the moelle osseuse, dependamment des IFN de type I.
Journal ArticleDOI
Anesthesia and developing brain: What have we learned from recent studies
Yi-Xuan Niu,Jia Yan,Hong Jiang +2 more
TL;DR: In this article , a review summarizes recent progress made in clinical and preclinical studies to provide useful suggestions and potential therapeutic targets for the protection of the immature brain from general anesthetics.
Journal ArticleDOI
Comprehensive molecular analysis of a four-pyroptosis-gene signature with prognosis and immune landscape in lung adenocarcinoma.
TL;DR: Wang et al. as discussed by the authors identified 41 pyroptosis regulators differently expressed in lung adenocarcinoma (LUAD), and all cases of LUAD can be classified into two molecular subtypes using unsupervised clustering algorithm.
Journal ArticleDOI
The Role of Amino Acid Metabolism of Tumor Associated Macrophages in the Development of Colorectal Cancer
TL;DR: In this paper , the effect of amino acid metabolism on macrophage function and the involved mechanism was investigated based on the comprehensive analysis of the GSE18804 GEO dataset.
Journal ArticleDOI
The changes in pyroptosis-related inflammatory factors in the peripheral blood of patients with Henoch-Schonlein purpura
Jinpeng Wang,Yuyu Zheng,Genwang Chen,Yiming Lv,Fen Lian,Daqi Jiang,Wanhong Ke,Lili Liu,Chunmei Fan,Sisi Gong +9 more
TL;DR: In this paper, the variation of pyroptosis-related inflammatory factors level in the peripheral blood of patients with Henoch-Schonlein purpura (HSP) was explored.
References
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Journal ArticleDOI
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
TL;DR: In this article, the inflammasome is identified as a caspase-activating complex that comprises caspases-1, casp-5, Pycard/Asc, and NALP1, a Pyrin domain-containing protein sharing structural homology with NODs.
Journal ArticleDOI
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Jianjin Shi,Yue Zhao,Kun Wang,Xuyan Shi,Wang Yue,Huanwei Huang,Yinghua Zhuang,Tao Cai,Fengchao Wang,Feng Shao +9 more
TL;DR: Gasdermin D (Gsdmd) is identified by genome-wide clustered regularly interspaced palindromic repeat-Cas9 nuclease screens of caspase-11- and caspasing-1-mediated pyroptosis in mouse bone marrow macrophages to offer insight into inflammasome-mediated immunity/diseases and change the understanding of pyroPTosis and programmed necrosis.
Journal ArticleDOI
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
Guido Kroemer,Guido Kroemer,Guido Kroemer,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Peter Vandenabeele,John M. Abrams,Emad S. Alnemri,Eric H. Baehrecke,Mikhail V. Blagosklonny,Wafik S. El-Deiry,Pierre Golstein,Pierre Golstein,Douglas R. Green,Michael O. Hengartner,Richard A. Knight,Sharad Kumar,Stuart A. Lipton,Stuart A. Lipton,Stuart A. Lipton,Walter Malorni,Gabriel Núñez,Marcus E. Peter,Juerg Tschopp,Junying Yuan,Mauro Piacentini,Boris Zhivotovsky,Gerry Melino,Gerry Melino +29 more
TL;DR: This study details the 2009 recommendations of the NCCD on the use of cell death-related terminology including ‘entosis’, ‘mitotic catastrophe”,’ ‘necrosis‚ ‘necroptosis‚’ and ‘pyroptotic’.
Journal ArticleDOI
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.
Nancy A. Thornberry,Herbert G. Bull,Jimmy R. Calaycay,Kevin T. Chapman,Andrew D. Howard,Matthew J. Kostura,Douglas K. Miller,Susan M. Molineaux,Jeffrey R. Weidner,John G. Aunins,Keith O. Elliston,Julia M. Ayala,Francesca J. Casano,Jayne Chin,Gloria J.-F. Ding,Linda A. Egger,Erin P. Gaffney,Guadalupe A. Limjuco,Oksana C. Palyha,S.M. Raju,Anna M. Rolando,J. Paul Salley,Ting-Ting Yamin,Terry D. Lee,John E. Shively,Malcolm MacCross,Richard A. Mumford,John A. Schmidt,Michael J. Tocci +28 more
TL;DR: Purification and cloning of the complementary DNA indicates that IL-lβ-converting enzyme is composed of two nonidentical subunits that are derived from a single proenzyme, possibly by autoproteolysis.
Journal ArticleDOI
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nobuhiko Kayagaki,Irma B. Stowe,Bettina L. Lee,Karen O'Rourke,Keith R. Anderson,Søren Warming,Trinna L. Cuellar,Benjamin Haley,Merone Roose-Girma,Qui T. Phung,Peter Liu,Jennie R. Lill,Hong Li,Jiansheng Wu,Sarah K. Kummerfeld,Juan Zhang,Wyne P. Lee,Scott J. Snipas,Guy S. Salvesen,Lucy X. Morris,Linda Fitzgerald,Yafei Zhang,Edward M. Bertram,Christopher C. Goodnow,Christopher C. Goodnow,Christopher C. Goodnow,Vishva M. Dixit +26 more
TL;DR: It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.
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Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nobuhiko Kayagaki,Irma B. Stowe,Bettina L. Lee,Karen O'Rourke,Keith R. Anderson,Søren Warming,Trinna L. Cuellar,Benjamin Haley,Merone Roose-Girma,Qui T. Phung,Peter Liu,Jennie R. Lill,Hong Li,Jiansheng Wu,Sarah K. Kummerfeld,Juan Zhang,Wyne P. Lee,Scott J. Snipas,Guy S. Salvesen,Lucy X. Morris,Linda Fitzgerald,Yafei Zhang,Edward M. Bertram,Christopher C. Goodnow,Christopher C. Goodnow,Christopher C. Goodnow,Vishva M. Dixit +26 more