Journal ArticleDOI
Pyroptosis: Gasdermin-Mediated Programmed Necrotic Cell Death
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TLDR
The discovery of caspase-11/4/5 function in sensing intracellular lipopolysaccharide expands the spectrum of pyroptosis mediators and also reveals that pyroPTosis is not cell type specific.About:
This article is published in Trends in Biochemical Sciences.The article was published on 2017-04-01. It has received 1611 citations till now. The article focuses on the topics: Pyroptosis & Pore forming protein.read more
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Pyroptosis in development, inflammation and disease
TL;DR: Findings that help define the roles of inflammasomes, inflammatory caspases, gasdermins, and other mediators of pyroptosis are summarized and how they determine cell fate and regulate disease progression is summarized.
Journal ArticleDOI
The Burkholderia cenocepacia Type VI Secretion System Effector TecA Is a Virulence Factor in Mouse Models of Lung Infection.
Nicole A. Loeven,Andrew I. Perault,Peggy A. Cotter,Craig A. Hodges,Joseph D. Schwartzman,Thomas H. Hampton,James B. Bliska +6 more
TL;DR: In this paper, the authors used the type VI secretion system (T6SS) effector TecA of B. cenocepacia to demonstrate that TecA exacerbates inflammatory cell recruitment and weight loss and is required for lethality.
Journal ArticleDOI
NLRP3 and mTOR Reciprocally Regulate Macrophage Phagolysosome Formation and Acidification Against Vibrio vulnificus Infection.
Xian-Hui Huang,Yao Ma,Yao Ma,Meng-Meng Zheng,Meng-Meng Zheng,Na Chen,Na Chen,Mei-Na Hu,Mei-Na Hu,Liu-Ying Wu,Liu-Ying Wu,Yi Zheng,Yi Zheng,Yong-Liang Lou,Yong-Liang Lou,Dan-Li Xie,Dan-Li Xie +16 more
TL;DR: It is found that the bactericidal activity of macrophages to internalize V. vulnificus was dependent on mammalian target of rapamycin (mTOR) and NOD-like receptor (NLR) family pyrin domain containing 3 (NLRP3) interaction, and mTORC1 signaling overactivation could increase NLRP3 expression and restore insufficient phagosome acidification.
Journal ArticleDOI
Edwardsiella tarda triggers the pyroptosis of the macrophage of Japanese flounder (Paralichthys olivaceus)
Xuangang Wang,Xiangfu Kong,Xiaobing Liu,Xubo Wang,Zhigang Wang,Jinxiang Liu,Quanqi Zhang,Haiyang Yu +7 more
TL;DR: The expression levels of pyroptosis-related genes and inflammatory cytokines were substantially up-regulated after E. tarda infection, implying that pyroPTosis was associated with caspase-1, which could improve the understanding of the immune mechanism underlying the resistance of teleosts to pathogen invasion.
Journal ArticleDOI
PRRSV Infection Induces Gasdermin D-Driven Pyroptosis of Porcine Alveolar Macrophages through NLRP3 Inflammasome Activation
Sheng He,Lucen Li,Haifan Chen,X. Hu,Wendi Wang,Hui Zhang,Ruiping Wei,Xiaoxiao Zhang,Yaosheng Chen,Xiaodong Liu +9 more
TL;DR: It is demonstrated that PRRSV infection triggered gasdermin D-mediated host pyroptosis in vitro and in vivo, and the results indicated that TMEM41B, an endoplasmic reticulum (ER)-resident host protein, functioned as a crucial host factor in the formation ofPRRSV RTC, which is surrounded by the intermediate filament network.
References
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Journal ArticleDOI
The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta.
TL;DR: In this article, the inflammasome is identified as a caspase-activating complex that comprises caspases-1, casp-5, Pycard/Asc, and NALP1, a Pyrin domain-containing protein sharing structural homology with NODs.
Journal ArticleDOI
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Jianjin Shi,Yue Zhao,Kun Wang,Xuyan Shi,Wang Yue,Huanwei Huang,Yinghua Zhuang,Tao Cai,Fengchao Wang,Feng Shao +9 more
TL;DR: Gasdermin D (Gsdmd) is identified by genome-wide clustered regularly interspaced palindromic repeat-Cas9 nuclease screens of caspase-11- and caspasing-1-mediated pyroptosis in mouse bone marrow macrophages to offer insight into inflammasome-mediated immunity/diseases and change the understanding of pyroPTosis and programmed necrosis.
Journal ArticleDOI
Classification of cell death: recommendations of the Nomenclature Committee on Cell Death
Guido Kroemer,Guido Kroemer,Guido Kroemer,Lorenzo Galluzzi,Lorenzo Galluzzi,Lorenzo Galluzzi,Peter Vandenabeele,John M. Abrams,Emad S. Alnemri,Eric H. Baehrecke,Mikhail V. Blagosklonny,Wafik S. El-Deiry,Pierre Golstein,Pierre Golstein,Douglas R. Green,Michael O. Hengartner,Richard A. Knight,Sharad Kumar,Stuart A. Lipton,Stuart A. Lipton,Stuart A. Lipton,Walter Malorni,Gabriel Núñez,Marcus E. Peter,Juerg Tschopp,Junying Yuan,Mauro Piacentini,Boris Zhivotovsky,Gerry Melino,Gerry Melino +29 more
TL;DR: This study details the 2009 recommendations of the NCCD on the use of cell death-related terminology including ‘entosis’, ‘mitotic catastrophe”,’ ‘necrosis‚ ‘necroptosis‚’ and ‘pyroptotic’.
Journal ArticleDOI
A novel heterodimeric cysteine protease is required for interleukin-1 beta processing in monocytes.
Nancy A. Thornberry,Herbert G. Bull,Jimmy R. Calaycay,Kevin T. Chapman,Andrew D. Howard,Matthew J. Kostura,Douglas K. Miller,Susan M. Molineaux,Jeffrey R. Weidner,John G. Aunins,Keith O. Elliston,Julia M. Ayala,Francesca J. Casano,Jayne Chin,Gloria J.-F. Ding,Linda A. Egger,Erin P. Gaffney,Guadalupe A. Limjuco,Oksana C. Palyha,S.M. Raju,Anna M. Rolando,J. Paul Salley,Ting-Ting Yamin,Terry D. Lee,John E. Shively,Malcolm MacCross,Richard A. Mumford,John A. Schmidt,Michael J. Tocci +28 more
TL;DR: Purification and cloning of the complementary DNA indicates that IL-lβ-converting enzyme is composed of two nonidentical subunits that are derived from a single proenzyme, possibly by autoproteolysis.
Journal ArticleDOI
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Nobuhiko Kayagaki,Irma B. Stowe,Bettina L. Lee,Karen O'Rourke,Keith R. Anderson,Søren Warming,Trinna L. Cuellar,Benjamin Haley,Merone Roose-Girma,Qui T. Phung,Peter Liu,Jennie R. Lill,Hong Li,Jiansheng Wu,Sarah K. Kummerfeld,Juan Zhang,Wyne P. Lee,Scott J. Snipas,Guy S. Salvesen,Lucy X. Morris,Linda Fitzgerald,Yafei Zhang,Edward M. Bertram,Christopher C. Goodnow,Christopher C. Goodnow,Christopher C. Goodnow,Vishva M. Dixit +26 more
TL;DR: It is shown that gasdermin D is essential for caspase-11-dependent pyroptosis and interleukin-1β maturation and a key mediator of the host response against Gram-negative bacteria.
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