Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence.
Masashi Narita,Sabrina Nuñez,Sabrina Nuñez,Edith Heard,Masako Narita,Athena W. Lin,Stephen Hearn,David L. Spector,Gregory J. Hannon,Scott W. Lowe +9 more
TLDR
A distinct heterochromatic structure that accumulates in senescent human fibroblasts is described, which is designated senescence-associated heterochROMatic foci (SAHF) and is associated with the stable repression of E2F target genes.About:
This article is published in Cell.The article was published on 2003-06-13 and is currently open access. It has received 2055 citations till now. The article focuses on the topics: Senescence-associated heterochromatin focus & E2F.read more
Citations
More filters
Journal ArticleDOI
Characterization of the p53 response to oncogene-induced senescence.
Lidia Ruiz,Magali Traskine,Irene Ferrer,Estrella Castro,Juan F. M. Leal,Marcelline Kaufman,Amancio Carnero +6 more
TL;DR: PPP1CA (the catalytic subunit of PP1α), recently identified as contributing to Ras-induced senescence, might be this second signal contributing to the irreversibility of the senescent phenotype, which is suggested to be a Ras-dependent, p53-independent, second signal.
Journal Article
A comprehensive review of the roles of E2F1 in colon cancer.
TL;DR: The first review that aims to consider and dissect all of the elucidated complex behaviors of E2F1 in colon cancer is provided, which provides an analysis and conclusion regarding the current understanding of E 2F1In colon cancer in order to facilitate the direction of future research.
Journal ArticleDOI
Astrocyte Support for Oligodendrocyte Differentiation can be Conveyed via Extracellular Vesicles but Diminishes with Age
Cory M. Willis,Alexandra M. Nicaise,Ernesto R. Bongarzone,Maria I. Givogri,Cory R. Reiter,Olivia Heintz,Evan R. Jellison,Pearl A. Sutter,Gregg TeHennepe,Guruprasad Ananda,Anthony T. Vella,Stephen J. Crocker +11 more
TL;DR: Evidence is provided that astrocytes aged in culture develop a spontaneous pro-inflammatory and senescence-like phenotype, and the negative influence of culture age on astroCytes, and their cognate EVs, could be countered by treatment with rapamycin.
Journal ArticleDOI
Selective Ablation of Retinoblastoma Protein Function by the RET Finger Protein
Maja Krützfeldt,Mark Ellis,Daniel Weekes,Jonathan J. Bull,Martin Eilers,Maria dM Vivanco,William R. Sellers,Sibylle Mittnacht +7 more
TL;DR: In this paper, the RET finger protein (RFP)/tripartite motif protein 27 (TRIM 27) was shown to inhibit gene transcription activation by Rb but does not affect gene repression.
Journal ArticleDOI
E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis
Kamil Wolyniec,Kamil Wolyniec,Jake Shortt,Jake Shortt,Elisa de Stanchina,Yaara Levav-Cohen,Osnat Alsheich-Bartok,Igal Louria-Hayon,Vincent Corneille,Vincent Corneille,Beena Kumar,Simone J Woods,Simone J Woods,Stephen Opat,Ricky W. Johnstone,Ricky W. Johnstone,Clare L. Scott,Clare L. Scott,David J. Segal,Pier Paolo Pandolfi,Stephen B. Fox,Stephen B. Fox,Andreas Strasser,Andreas Strasser,Yong-hui Jiang,Scott W. Lowe,Sue Haupt,Sue Haupt,Ygal Haupt +28 more
TL;DR: It is demonstrated that E6AP-mediated down-regulation of PML-induced senescence is essential for B-cell lymphoma progression, and this provides a molecular explanation for the down- regulation ofPML observed in non-Hodgkin lymphomas, thereby suggesting a novel therapeutic approach for restoration of tumor suppression in B- cell lymphoma.
References
More filters
Journal ArticleDOI
A biomarker that identifies senescent human cells in culture and in aging skin in vivo
Goberdhan P. Dimri,X Lee,G Basile,Meileen Acosta,G Scott,C Roskelley,E E Medrano,Maarten H.K. Linskens,Ivica Rubelj,Olivia M. Pereira-Smith +9 more
TL;DR: It is shown that several human cells express a beta-galactosidase, histochemically detectable at pH 6, upon senescence in culture, which provides in situ evidence that senescent cells may exist and accumulate with age in vivo.
Journal ArticleDOI
The limited in vitro lifetime of human diploid cell strains
TL;DR: The survival curves obtained with human diploid cell strains are comparable to “multiple-hit” or “ multiple-target” curves obtain with other biological systems where an initial threshold dose is required before an exponential form of the curve is established.
Journal ArticleDOI
Oncogenic ras Provokes Premature Cell Senescence Associated with Accumulation of p53 and p16INK4a
TL;DR: It is shown that expression of oncogenic ras in primary human or rodent cells results in a permanent G1 arrest, and that the onset of cellular senescence does not simply reflect the accumulation of cell divisions, but can be prematurely activated in response to an onCogenic stimulus.
Journal ArticleDOI
Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins.
TL;DR: It is shown that mammalian methyltransferases that selectively methylate histone H3 on lysine 9 (Suv39h HMTases) generate a binding site for HP1 proteins—a family of heterochromatic adaptor molecules implicated in both gene silencing and supra-nucleosomal chromatin structure.
Journal ArticleDOI
Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain.
Andrew J. Bannister,Philip Zegerman,Janet F. Partridge,Eric A. Miska,Jean O. Thomas,Robin C. Allshire,Tony Kouzarides +6 more
TL;DR: A stepwise model for the formation of a transcriptionally silent heterochromatin is provided: SUV39H1 places a ‘methyl marker’ on histone H3, which is then recognized by HP1 through its chromo domain, which may also explain the stable inheritance of theheterochromatic state.