Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease.
Susan K. Murphy,Hyuna Yang,Cynthia A. Moylan,Herbert Pang,Andrew Dellinger,Manal F. Abdelmalek,Melanie E. Garrett,Allison E. Ashley Koch,Ayako Suzuki,Hans L. Tillmann,Michael A. Hauser,Anna Mae Diehl +11 more
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TLDR
Altered methylation of genes that regulate processes such as steatohepatitis, fibrosis, and carcinogenesis indicate the role of DNA methylation in progression of NAFLD.About:
This article is published in Gastroenterology.The article was published on 2013-11-01 and is currently open access. It has received 300 citations till now. The article focuses on the topics: Nonalcoholic fatty liver disease & Fatty liver.read more
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Journal ArticleDOI
Genetic and Epigenetic Associations with NAFLD: Focus on Clinical Decision Making and Novel Concepts in Disease Pathogenesis
TL;DR: New findings about current genome-wide association studies on NAFLD are summarized and controversies on the application of genetic testing to predict disease severity are discussed and specifically the role of rs738409 in clinical decision making are discussed.
Journal ArticleDOI
Mechanisms of Fibrosis in Steatohepatitis
TL;DR: Recent data on the basic mechanisms leading to the development of fibrosis in nonalcoholic steatohepatitis are discussed, in particular those which may identify novel approaches to treatment.
Book ChapterDOI
Genetic Basis of Alcoholic and Nonalcoholic Fatty Liver Disease
TL;DR: Nonalcoholic fatty liver disease (NAFLD) and alcoholic fatty liver diseased are both leading causes of nonviral chronic liver diseases, and the prevalence of these two clinical disorders is constantly growing worldwide.
Journal ArticleDOI
Regulation of P300 and HDAC1 on endoplasmic reticulum stress in isoniazid‐induced HL‐7702 hepatocyte injury
TL;DR: It is confirmed that isoniazid can change the states of P300 and HDAC1 in HL‐7702 hepatocyte metabolism and induce ERS, causing hepatocyte injury and apoptosis, and changes in P 300 andHDAC1 can regulate ERS and then affect cell damage.
References
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The diagnosis and management of non-alcoholic fatty liver disease: practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association
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The accessible chromatin landscape of the human genome
Robert E. Thurman,Eric Rynes,Richard Humbert,Jeff Vierstra,Matthew T. Maurano,Eric Haugen,Nathan C. Sheffield,Andrew B. Stergachis,Hao Wang,Benjamin Vernot,Kavita Garg,Sam John,Richard Sandstrom,Daniel Bates,Lisa Boatman,Theresa K. Canfield,Morgan Diegel,Douglas Dunn,Abigail K. Ebersol,Tristan Frum,Erika Giste,Audra K. Johnson,Ericka M. Johnson,Tanya Kutyavin,Bryan R. Lajoie,Bum Kyu Lee,Kristen Lee,Darin London,Dimitra Lotakis,Shane Neph,Fidencio Neri,Eric D. Nguyen,Hongzhu Qu,Hongzhu Qu,Alex Reynolds,Vaughn Roach,Alexias Safi,Minerva E. Sanchez,Amartya Sanyal,Anthony Shafer,Jeremy M. Simon,Lingyun Song,Shinny Vong,Molly Weaver,Yongqi Yan,Zhancheng Zhang,Zhuzhu Zhang,Boris Lenhard,Muneesh Tewari,Michael O. Dorschner,R. Scott Hansen,Patrick A. Navas,George Stamatoyannopoulos,Vishwanath R. Iyer,Jason D. Lieb,Shamil R. Sunyaev,Joshua M. Akey,Peter J. Sabo,Rajinder Kaul,Terrence S. Furey,Job Dekker,Gregory E. Crawford,John A. Stamatoyannopoulos,John A. Stamatoyannopoulos +63 more
TL;DR: The first extensive map of human DHSs identified through genome-wide profiling in 125 diverse cell and tissue types is presented, revealing novel relationships between chromatin accessibility, transcription, DNA methylation and regulatory factor occupancy patterns.
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Dna methylation and human disease
TL;DR: A large number of human diseases have been found to be associated with aberrant DNA methylation and the study of these diseases has provided new and fundamental insights into the roles that DNAmethylation and other epigenetic modifications have in development and normal cellular homeostasis.
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The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores.
Rafael A. Irizarry,Christine Ladd-Acosta,Bo Wen,Zhijin Wu,Carolina Montano,Patrick Onyango,Hengmi Cui,Kevin Gabo,Michael Rongione,Maree J. Webster,Hong-Fei Ji,James B. Potash,Sarven Sabunciyan,Andrew P. Feinberg +13 more
TL;DR: Methylation changes in cancer are at sites that vary normally in tissue differentiation, consistent with the epigenetic progenitor model of cancer, which proposes that epigenetic alterations affecting tissue-specific differentiation are the predominant mechanism by which epigenetic changes cause cancer.