Relationship between methylome and transcriptome in patients with nonalcoholic fatty liver disease.
Susan K. Murphy,Hyuna Yang,Cynthia A. Moylan,Herbert Pang,Andrew Dellinger,Manal F. Abdelmalek,Melanie E. Garrett,Allison E. Ashley Koch,Ayako Suzuki,Hans L. Tillmann,Michael A. Hauser,Anna Mae Diehl +11 more
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TLDR
Altered methylation of genes that regulate processes such as steatohepatitis, fibrosis, and carcinogenesis indicate the role of DNA methylation in progression of NAFLD.About:
This article is published in Gastroenterology.The article was published on 2013-11-01 and is currently open access. It has received 300 citations till now. The article focuses on the topics: Nonalcoholic fatty liver disease & Fatty liver.read more
Citations
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Journal ArticleDOI
NAFLD-Associated HCC: Progress and Opportunities.
TL;DR: The IMBrave150 study as discussed by the authors showed that NAFLD-associated hepatocellular carcinoma (HCC) tends to present at an advanced stage in older patients with co-morbidities.
Journal ArticleDOI
Methylation of the FGFR2 gene is associated with high birth weight centile in humans.
Kim E. Haworth,William E. Farrell,Richard D. Emes,Khaled M K Ismail,Will Carroll,Emma Hubball,Angela Rooney,Alexandra M Yates,Charles A. Mein,Anthony A. Fryer +9 more
TL;DR: A novel biologically plausible candidate (FGFR2) for with BWC that merits further study is identified.
Journal ArticleDOI
A blood-based prognostic liver secretome signature and long-term hepatocellular carcinoma risk in advanced liver fibrosis
Naoto Fujiwara,Naoto Fujiwara,Masahiro Kobayashi,Austin J. Fobar,Ayaka Hoshida,Cesia A. Marquez,Bhuvaneswari Koneru,Gayatri Panda,Masataka Taguri,Tongqi Qian,Indu Raman,Quan Zhen Li,Hiroki Hoshida,Hitomi Sezaki,Hiromitsu Kumada,Ryosuke Tateishi,Takeshi Yokoo,Adam C. Yopp,Raymond T. Chung,Bryan C. Fuchs,Bryan C. Fuchs,Thomas F. Baumert,Jorge A. Marrero,Neehar D. Parikh,Shijia Zhu,Amit G. Singal,Yujin Hoshida +26 more
TL;DR: The blood-based PLSec-AFP can accurately stratify patients with advanced liver fibrosis for long-term HCC risk and thereby guide risk-based tailored HCC screening.
Journal ArticleDOI
Modelling non-alcoholic fatty liver disease in human hepatocyte-like cells
Marcus J. Lyall,Jessy Cartier,John P. Thomson,Katherine Cameron,Jose Meseguer-Ripolles,Eoghan O'Duibhir,Dagmara Szkolnicka,Baltasar Lucendo Villarin,Yu Wang,Giovanny Rodriguez Blanco,Warwick B. Dunn,Richard R. Meehan,David C. Hay,Amanda J. Drake +13 more
TL;DR: This in vitro model of NAFLD using HLCs exposed to lactate, pyruvate and octanoic acid that bear all the hallmarks, including 5hmC profiles, of liver functionality is developed and will be useful for future mechanistic and therapeutic studies.
Book ChapterDOI
Sphingolipids at the Crossroads of NAFLD and Senescence
TL;DR: Solid support is provided to the notion that deregulated ceramide and sphingosine‐1‐phosphate metabolism are present at all stages of NAFLD, i.e., steatosis, nonalcoholic steatohepatitis, advanced fibrosis, and hepatocellular carcinoma.
References
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Dna methylation and human disease
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The human colon cancer methylome shows similar hypo- and hypermethylation at conserved tissue-specific CpG island shores.
Rafael A. Irizarry,Christine Ladd-Acosta,Bo Wen,Zhijin Wu,Carolina Montano,Patrick Onyango,Hengmi Cui,Kevin Gabo,Michael Rongione,Maree J. Webster,Hong-Fei Ji,James B. Potash,Sarven Sabunciyan,Andrew P. Feinberg +13 more
TL;DR: Methylation changes in cancer are at sites that vary normally in tissue differentiation, consistent with the epigenetic progenitor model of cancer, which proposes that epigenetic alterations affecting tissue-specific differentiation are the predominant mechanism by which epigenetic changes cause cancer.