S100A8/A9 in Inflammation.
TLDR
A comprehensive and detailed overview of the distribution and biological functions of S100A8/A9 is provided and its application as a diagnostic and therapeutic target in inflammation-associated diseases is highlighted.Abstract:
S100A8 and S100A9 (also known as MRP8 and MRP14, respectively) are Ca2+ binding proteins belonging to the S100 family. They often exist in the form of heterodimer, while homodimer exists very little because of the stability. S100A8/A9 is constitutively expressed in neutrophils and monocytes as a Ca2+ sensor, participating in cytoskeleton rearrangement and arachidonic acid metabolism. During inflammation, S100A8/A9 is released actively and exerts a critical role in modulating the inflammatory response by stimulating leukocyte recruitment and inducing cytokine secretion. S100A8/A9 serves as a candidate biomarker for diagnosis and follow-up as well as a predictive indicator of therapeutic responses to inflammation-associated diseases. As blockade of S100A8/A9 activity using small-molecule inhibitors or antibodies improves pathological conditions in murine models, the heterodimer has potential as a therapeutic target. In this review, we provide a comprehensive and detailed overview of the distribution and biological functions of S100A8/A9 and highlight its application as a diagnostic and therapeutic target in inflammation-associated diseases.read more
Citations
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Elevated Calprotectin and Abnormal Myeloid Cell Subsets Discriminate Severe from Mild COVID-19.
Aymeric Silvin,Nicolas Chapuis,Garett Dunsmore,Anne-Gaëlle Goubet,Agathe Dubuisson,Lisa Derosa,Carole Almire,Clémence Hénon,Olivier Kosmider,Nathalie Droin,Philippe Rameau,Cyril Catelain,Alexia Alfaro,Charles Dussiau,Chloé Friedrich,Elise Sourdeau,Nathalie Marin,T.-A. Szwebel,Delphine Cantin,Luc Mouthon,Didier Borderie,Marc Deloger,Delphine Bredel,Severine Mouraud,Damien Drubay,Muriel Andrieu,Anne-Sophie Lhonneur,Véronique Saada,Annabelle Stoclin,Christophe Willekens,Fanny Pommeret,Frank Griscelli,Lai Guan Ng,Zheng Zhang,Pierre Bost,Pierre Bost,Ido Amit,Fabrice Barlesi,Aurélien Marabelle,Frédéric Pène,Bertrand Gachot,Fabrice Andre,Fabrice Andre,Laurence Zitvogel,Laurence Zitvogel,Laurence Zitvogel,Florent Ginhoux,Florent Ginhoux,Florent Ginhoux,Michaela Fontenay,Eric Solary,Eric Solary +51 more
TL;DR: It is shown that calprotectin plasma level and a routine flow cytometry assay detecting decreased frequencies of non-classical monocytes could discriminate patients who develop a severe COVID-19 form, suggesting a predictive value that deserves prospective evaluation.
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Sexual-dimorphism in human immune system aging.
Eladio J. Márquez,Cheng-han Chung,Radu Marches,Robert J. Rossi,Djamel Nehar-Belaid,Alper Eroglu,David J. Mellert,George A. Kuchel,Jacques Banchereau,Duygu Ucar,Duygu Ucar +10 more
TL;DR: Gene expression, chromatin state and immune subset composition in the blood of healthy humans 22 to 93 years of age is characterized, uncovering shared as well as sex-unique alterations, and a web resource is created to interactively explore the data.
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An immune-based biomarker signature is associated with mortality in COVID-19 patients.
Michael S. Abers,Ottavia M. Delmonte,Emily Ricotta,Jonathan Fintzi,Danielle Fink,Adriana Almeida de Jesus,Kol A. Zarember,Sara Alehashemi,Vasileios Oikonomou,Jigar V. Desai,Scott W. Canna,Bita Shakoory,Kerry Dobbs,Luisa Imberti,Alessandra Sottini,Eugenia Quiros-Roldan,Francesco Castelli,Camillo Rossi,Duilio Brugnoni,Andrea Biondi,Laura Rachele Bettini,Mariella D'Angiò,Paolo Bonfanti,Riccardo Castagnoli,Daniela Montagna,Amelia Licari,Gian Luigi Marseglia,Emily F. Gliniewicz,Elana Shaw,Dana Kahle,Andre Rastegar,Michael Stack,Katherine Myint-Hpu,Susan L Levinson,Mark J. DiNubile,Daniel W. Chertow,Peter D. Burbelo,Jeffrey I. Cohen,Katherine R. Calvo,John S. Tsang,Helen C. Su,John I. Gallin,Douglas B. Kuhns,Raphaela Goldbach-Mansky,Michail S. Lionakis,Luigi D. Notarangelo +45 more
TL;DR: Levels of sST2, sTNFRSF1A, IL-10, and IL-15 were consistently higher throughout the hospitalization in patients who died versus those who recovered, suggesting that these biomarkers may provide an early warning of eventual disease outcome.
Journal ArticleDOI
Distinct synovial tissue macrophage subsets regulate inflammation and remission in rheumatoid arthritis.
Stefano Alivernini,Lucy MacDonald,Aziza Elmesmari,Samuel Finlay,Barbara Tolusso,Maria Rita Gigante,Luca Petricca,Clara Di Mario,Laura Bui,Simone Perniola,Moustafa Attar,Marco Gessi,Anna Laura Fedele,Sabarinadh Chilaka,Domenico Somma,Stephen N. Sansom,Andrew Filer,Andrew Filer,Charles McSharry,Neal L. Millar,Kristina Kirschner,Alessandra Nerviani,Myles Lewis,Costantino Pitzalis,Andrew R. Clark,Gianfranco Ferraccioli,Irina A. Udalova,Christopher D. Buckley,Elisa Gremese,Elisa Gremese,Iain B. McInnes,Thomas D. Otto,Mariola Kurowska-Stolarska +32 more
TL;DR: Multiple subpopulations of synovial tissue macrophages with varied transcriptional, phenotypic and functional features may contribute to disease flare and tissue repair in patients with active rheumatoid arthritis and patients in clinical remission.
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Plasma Proteomics Identify Biomarkers and Pathogenesis of COVID-19.
Ting Shu,Wanshan Ning,Di Wu,Jiqian Xu,Qiangqiang Han,Muhan Huang,Xiaojing Zou,Qingyu Yang,Yang Yuan,Yuanyuan Bie,Shangwen Pan,Jingfang Mu,Yang Han,Xiaobo Yang,Hong Zhou,Ruiting Li,Yujie Ren,Xi Chen,Shanglong Yao,Yang Qiu,Ding Yu Zhang,Yu Xue,You Shang,Xi Zhou +23 more
TL;DR: A machine learning-based pipeline was developed to identify 11 proteins as biomarkers and a set of biomarker combinations, which were validated by an independent cohort and accurately distinguished and predicted COVID-19 outcomes.
References
More filters
Journal ArticleDOI
Alzheimer's Disease: Genes, Proteins, and Therapy
TL;DR: Evidence that the presenilin proteins, mutations in which cause the most aggressive form of inherited AD, lead to altered intramembranous cleavage of the beta-amyloid precursor protein by the protease called gamma-secretase has spurred progress toward novel therapeutics and provided discrete biochemical targets for drug screening and development.
Journal ArticleDOI
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
Thomas Vogl,Klaus Tenbrock,Stephan Ludwig,Nadja Leukert,Christina Ehrhardt,Marieke A. D. van Zoelen,Wolfgang Nacken,Dirk Foell,Tom van der Poll,Clemens Sorg,Johannes Roth +10 more
TL;DR: It is demonstrated that mice lacking Mrp8-Mrp14 complexes are protected from endotoxin-induced lethal shock and Escherichia coli–induced abdominal sepsis, indicating new inflammatory components that amplify phagocyte activation during sepsi upstream of TNFα–dependent effects.
Journal ArticleDOI
Metal Chelation and Inhibition of Bacterial Growth in Tissue Abscesses
Brian D. Corbin,Erin H. Seeley,Andrea Raab,Joerg Feldmann,Michael R. Miller,Victor J. Torres,Kelsi L. Anderson,Brian M. Dattilo,Paul M. Dunman,Russell Gerads,Richard M. Caprioli,Wolfgang Nacken,Walter J. Chazin,Eric P. Skaar +13 more
TL;DR: It is demonstrated that calprotectin is a critical factor in the innate immune response to infection and metal chelation as a strategy for inhibiting microbial growth inside abscessed tissue is defined.
Journal ArticleDOI
Proinflammatory Activities of S100: Proteins S100A8, S100A9, and S100A8/A9 Induce Neutrophil Chemotaxis and Adhesion
TL;DR: S100A8, S100A9, and S 100A8/A9 are potent stimulators of neutrophils and strongly suggest that these proteins are involved in neutrophil migration to inflammatory sites.
Journal ArticleDOI
Nutritional immunity beyond iron: a role for manganese and zinc
Thomas E. Kehl-Fie,Eric P. Skaar +1 more
TL;DR: Limiting the availability of zinc and manganese as a mechanism to defend against infection expands the spectrum of nutritional immunity and further establishes metal sequestration as a key defense against microbial invaders.
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