Systemic and organ-specific immune-related manifestations of COVID-19.
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TLDR
The signs and symptoms associated with this excessive immune response are very diverse and can resemble some autoimmune or inflammatory diseases, with the clinical phenotype that is seemingly influenced by epidemiological factors such as age, sex or ethnicity.Citations
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Symptoms and risk factors for long COVID in non-hospitalized adults
Anuradha Subramanian,Krishnarajah Nirantharakumar,S. Hughes,Puja R. Myles,Timothy J. Williams,Krishna Gokhale,Thomas Taverner,Joht Singh Chandan,Kirsty Brown,N. Simms-Williams,Anoop D. Shah,Megha Singh,Farah F. Kidy,Kelvin Okoth,Richard Hotham,Nasir Zeeshan Bashir,N Cockburn,Siang Ing Lee,Grace M Turner,Georgios V. Gkoutos,Olalekan Lee Aiyegbusi,Christel McMullan,Alastair K Denniston,Elizabeth Sapey,Janet M. Lord,David C. Wraith,Edward Leggett,C. Iles,Tom Marshall,Malcolm J Price,Steven Marwaha,Elin Haf Davies,Louise E. Jackson,Katherine Matthews,J. Camaradou,M. Calvert,Shamil Haroon +36 more
TL;DR: In this paper , the authors conducted a study to determine symptoms associated with confirmed SARS-CoV-2 infection beyond 12 weeks in non-hospitalized adults and the risk factors associated with developing persistent symptoms.
Journal ArticleDOI
Symptoms and risk factors for long COVID in non-hospitalized adults
Anuradha Subramanian,Krishnarajah Nirantharakumar,S. Hughes,Puja R. Myles,Timothy J. Williams,Krishna Gokhale,Thomas Taverner,Joht Singh Chandan,Kirsty Brown,N. Simms-Williams,Anoop D. Shah,Megha Singh,Farah F. Kidy,Kelvin Okoth,Richard Hotham,Nasir Zeeshan Bashir,N Cockburn,Siang Ing Lee,Grace M Turner,Georgios V. Gkoutos,Olalekan Lee Aiyegbusi,Christel McMullan,Alastair K Denniston,Elizabeth Sapey,Janet M. Lord,David C. Wraith,Edward Leggett,C. Iles,Tom Marshall,Malcolm J Price,Steven Marwaha,Elin Haf Davies,Louise E. Jackson,Katherine Matthews,J. Camaradou,M. Calvert,Shamil Haroon +36 more
TL;DR: In this paper , the authors conducted a study to determine symptoms associated with confirmed SARS-CoV-2 infection beyond 12 weeks in non-hospitalized adults and the risk factors associated with developing persistent symptoms.
Journal ArticleDOI
The IL-1β, IL-6, and TNF cytokine triad is associated with post-acute sequelae of COVID-19
Christoph Schultheiß,Edith Willscher,Lisa Paschold,Cornelia Gottschick,B. Klee,S. Henkes,Lidia Bosurgi,Jochen Dutzmann,Daniel Sedding,Thomas Frese,Matthias Girndt,Jessica I. Höll,Michael Gekle,Rafael T. Mikolajczyk,Mascha Binder +14 more
TL;DR: In this paper , a digital epidemiology approach was used to find post-acute sequelae of COVID-19 (PASC), predominantly consisting of fatigue, dyspnea, and concentration deficit, which persists in 60% over the mean 8-month follow-up period.
Journal ArticleDOI
Long Covid-19: Proposed Primary Care Clinical Guidelines for Diagnosis and Disease Management.
Antoni Sisó-Almirall,Pilar Brito-Zerón,Laura Conangla Ferrín,Belchin Kostov,Anna Moragas Moreno,Jordi Mestres,Jaume Sellarès,Gisela Galindo,Ramon Morera,Josep Basora,Antoni Trilla,Manuel Ramos-Casals +11 more
TL;DR: In this paper, the authors defined long COVID-19 as patients who, four weeks after the diagnosis of SARS-Cov-2 infection, continue to have signs and symptoms not explainable by other causes.
Posted ContentDOI
Global Prevalence of Post-Acute Sequelae of COVID-19 (PASC) or Long COVID: A Meta-Analysis and Systematic Review
TL;DR: In this article, the authors examined the prevalence of post-acute sequelae of COVID-19 (PASC), commonly known as long COVID, across the world and to assess geographic heterogeneity through a systematic review and meta-analysis.
References
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Clinical Characteristics of Coronavirus Disease 2019 in China.
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TL;DR: During the first 2 months of the current outbreak, Covid-19 spread rapidly throughout China and caused varying degrees of illness, and patients often presented without fever, and many did not have abnormal radiologic findings.
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COVID-19: consider cytokine storm syndromes and immunosuppression
Puja Mehta,Daniel F. McAuley,Michael Brown,Emilie Sanchez,Rachel Tattersall,Rachel Tattersall,Jessica J Manson +6 more
TL;DR: Re-analysis of data from a phase 3 randomised controlled trial of IL-1 blockade (anakinra) in sepsis, showed significant survival benefit in patients with hyperinflammation, without increased adverse events.
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Remdesivir for the Treatment of Covid-19 - Final Report.
John H. Beigel,Kay M. Tomashek,Lori E. Dodd,Aneesh K. Mehta,Barry S. Zingman,Andre C. Kalil,Elizabeth L. Hohmann,Helen Y. Chu,Annie Luetkemeyer,Susan Kline,Diego Lopez de Castilla,Robert W. Finberg,Kerry Dierberg,Victor F. Tapson,Lanny Hsieh,Thomas F. Patterson,Roger Paredes,Daniel A. Sweeney,William R. Short,Giota Touloumi,David Chien Lye,Norio Ohmagari,Myoung-don Oh,Guillermo M. Ruiz-Palacios,Thomas Benfield,Gerd Fätkenheuer,Mark G. Kortepeter,Robert L. Atmar,C. Buddy Creech,JD Lundgren,Abdel G. Babiker,Sarah Pett,James D. Neaton,Timothy Burgess,Tyler Bonnett,Michelle Green,Mat Makowski,Anu Osinusi,Seema U Nayak,H. Clifford Lane +39 more
TL;DR: The data show that remdesivir was superior to placebo in shortening the time to recovery in adults who were hospitalized with Covid-19 and had evidence of lower respiratory tract infection.
Journal ArticleDOI
Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.
Ling Mao,Huijuan Jin,Mengdie Wang,Yu Hu,Shengcai Chen,Quan-Wei He,Jiang Chang,Candong Hong,Yifan Zhou,David Z. Wang,Xiaoping Miao,Yanan Li,Bo Hu +12 more
TL;DR: During the epidemic period of COVID-19, clinicians should suspect severe acute respiratory syndrome coronavirus 2 infection as a differential diagnosis to avoid delayed diagnosis or misdiagnosis and lose the chance to treat and prevent further transmission.
Journal ArticleDOI
HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis.
Jan-Inge Henter,AnnaCarin Horne,Maurizio Aricò,R. Maarten Egeler,Alexandra H. Filipovich,Shinsaku Imashuku,Stephan Ladisch,Kenneth L. McClain,David Webb,Jacek Winiarski,Gritta Janka +10 more
TL;DR: HLH‐2004 chemo‐immunotherapy includes etoposide, dexamethasone, cyclosporine A upfront and, in selected patients, intrathecal therapy with methotrexate and corticosteroids, and subsequent hematopoietic stem cell transplantation is recommended for patients with familial disease or molecular diagnosis, and patients with severe and persistent, or reactivated, disease.
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