Targeting the TGFβ signalling pathway in disease.
Rosemary J. Akhurst,Akiko Hata +1 more
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TLDR
Why the TGFβ signalling pathway is a drug target, the potential clinical applications of TGF β inhibition, the issues arising with anti-TGFβ therapy and how these might be tackled using personalized approaches to dosing, monitoring of biomarkers as well as brief and/or localized drug-dosing regimens are considered.Abstract:
Many drugs that target transforming growth factor-β (TGFβ) signalling have been developed, some of which have reached Phase III clinical trials for a number of disease applications. Preclinical and clinical studies indicate the utility of these agents in fibrosis and oncology, particularly in augmentation of existing cancer therapies, such as radiation and chemotherapy, as well as in tumour vaccines. There are also reports of specialized applications, such as the reduction of vascular symptoms of Marfan syndrome. Here, we consider why the TGFβ signalling pathway is a drug target, the potential clinical applications of TGFβ inhibition, the issues arising with anti-TGFβ therapy and how these might be tackled using personalized approaches to dosing, monitoring of biomarkers as well as brief and/or localized drug-dosing regimens.read more
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The Molecular Signatures Database Hallmark Gene Set Collection
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A Long Noncoding RNA Activated by TGF-β Promotes the Invasion-Metastasis Cascade in Hepatocellular Carcinoma
Ji-hang Yuan,Fu Yang,Fang Wang,Jin-zhao Ma,Yingjun Guo,Qi-fei Tao,Feng Liu,Wei Pan,Tian-tian Wang,Chuan-chuan Zhou,Shao-bing Wang,Yu-zhao Wang,Yuan Yang,Ning Yang,Weiping Zhou,Guang-Shun Yang,Shuhan Sun +16 more
TL;DR: Findings suggest that lncRNA-ATB, a mediator of TGF-β signaling, could predispose HCC patients to metastases and may serve as a potential target for antimetastatic therapies.
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The roles of TGFβ in the tumour microenvironment
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Estelle Bettelli,Yijun Carrier,Wenda Gao,Thomas Korn,Terry B. Strom,Mohamed Oukka,Howard L. Weiner,Vijay K. Kuchroo +7 more
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Yigong Shi,Joan Massagué +1 more
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Journal ArticleDOI
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Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Massimo Locati,Paola Allavena,Antonio Sica +5 more
TL;DR: These functionally polarized cells, and similarly oriented or immature dendritic cells present in tumors, have a key role in subversion of adaptive immunity and in inflammatory circuits that promote tumor growth and progression.
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