Journal ArticleDOI
The future of immune checkpoint therapy
Padmanee Sharma,James P. Allison +1 more
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TLDR
The way forward for this class of novel agents lies in the ability to understand human immune responses in the tumor microenvironment, which will provide valuable information regarding the dynamic nature of the immune response and regulation of additional pathways that will need to be targeted through combination therapies to provide survival benefit for greater numbers of patients.Abstract:
Immune checkpoint therapy, which targets regulatory pathways in T cells to enhance antitumor immune responses, has led to important clinical advances and provided a new weapon against cancer. This therapy has elicited durable clinical responses and, in a fraction of patients, long-term remissions where patients exhibit no clinical signs of cancer for many years. The way forward for this class of novel agents lies in our ability to understand human immune responses in the tumor microenvironment. This will provide valuable information regarding the dynamic nature of the immune response and regulation of additional pathways that will need to be targeted through combination therapies to provide survival benefit for greater numbers of patients.read more
Citations
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Opportunities for Small Molecules in Cancer Immunotherapy
TL;DR: An overview of how effects might be achieved by combining immunotherapy with conventional and/or new small-molecule chemotherapeutics with substantially improve efficacy of cancer immunotherapy is provided.
Journal ArticleDOI
A multi-center study on safety and efficacy of immune checkpoint inhibitors in cancer patients with kidney transplant
Naoka Murakami,Patrick M. Mulvaney,Melissa J. Danesh,Ala Abudayyeh,Adi Diab,Noha Abdel-Wahab,Maen Abdelrahim,Pascale Khairallah,Shayan Shirazian,Aleksandra Kukla,Itunu Owoyemi,Tarek Alhamad,Samir Husami,Madhav C. Menon,Andrew D. Santeusanio,Christopher D. Blosser,Sandra Carias Zuniga,María José Soler,Francesc Moreso,Zain Mithani,David I. Ortiz-Melo,Edgar A. Jaimes,Victoria Gutgarts,Erik L. Lum,Gabriel M. Danovitch,Francesca Cardarelli,Reed E. Drews,Claude Bassil,Jennifer L Swank,Scott G. Westphal,Roslyn B. Mannon,Keisuke Shirai,Abhijat Kitchlu,Song Ong,Shana Machado,Suraj Sarvode Mothi,Patrick A. Ott,Osama E. Rahma,F. Stephen Hodi,Meghan E. Sise,Shruti Gupta,David E. Leaf,Craig Devoe,Rimda Wanchoo,Vinay Nair,Chrysalyne D. Schmults,Glenn J. Hanna,Ben Sprangers,Leonardo V. Riella,Kenar D. Jhaveri +49 more
TL;DR: In this paper, the authors conducted a multicenter retrospective study of 69 patients with a kidney transplant receiving ICIs between January 2010 and May 2020, and assessed the incidence, timing, and risk factors of acute graft rejection.
Journal ArticleDOI
Microbiota in cancer development and treatment
Muhammad Hassan Raza,Kamni Gul,Abida Arshad,Naveeda Riaz,Usman Waheed,Abdul Rauf,Fahad M. Aldakheel,Shatha A. Alduraywish,Maqbool Ur Rehman,Muhammad Abdullah,Muhammad Arshad +10 more
TL;DR: Characterization of the microbiome particularly gut microbiota, understanding of the host–microbiota interactions, and its potential for therapeutic exploitation are necessary for the development of novel anticancer therapeutic strategies with better efficacy and lowered off-target side effects.
Journal ArticleDOI
Advanced small cell lung cancer (SCLC): new challenges and new expectations
Nikolaos Tsoukalas,Eleni Aravantinou-Fatorou,Panagiotis Baxevanos,Maria Tolia,Konstantinos Tsapakidis,Michail Galanopoulos,Michail Liontos,George Kyrgias +7 more
TL;DR: This review focuses on the new therapeutic strategies of SCLC, including immune-related treatment that may change the prognosis of the disease and the introduction of immunotherapy.
Journal ArticleDOI
Nanomedicine‐Boosting Tumor Immunogenicity for Enhanced Immunotherapy
Jing Huang,Jing Huang,Bin Yang,Yuan Peng,Jinsheng Huang,Siu Hong Dexter Wong,Liming Bian,Kangshun Zhu,Xintao Shuai,Shisong Han,Shisong Han,Shisong Han +11 more
TL;DR: This review highlights how nanomedicines integrating one or more anticancer therapeutic methods to increase the tumor immunogenicity for rousing T cell related immune responses and achieving inspiring antitumor efficacy in synergistic ways.
References
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Journal ArticleDOI
Improved Survival with Ipilimumab in Patients with Metastatic Melanoma.
F. Stephen Hodi,Steven J. O'Day,David F. McDermott,R. W. Weber,Jeffrey A. Sosman,John B. A. G. Haanen,Rene Gonzalez,Caroline Robert,Dirk Schadendorf,Jessica C. Hassel,Wallace Akerley,Alfons J.M. van den Eertwegh,Jose Lutzky,Paul Lorigan,Julia Vaubel,Gerald P. Linette,David W. Hogg,Christian H. Ottensmeier,Céleste Lebbé,Christian Peschel,Ian Quirt,Joseph I. Clark,Jedd D. Wolchok,Jeffrey S. Weber,Jason Tian,Michael Yellin,Geoffrey M. Nichol,Axel Hoos,Walter J. Urba +28 more
TL;DR: Ipilimumab, with or without a gp100 peptide vaccine, as compared with gp100 alone, improved overall survival in patients with previously treated metastatic melanoma.
Journal ArticleDOI
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer.
Suzanne L. Topalian,F. Stephen Hodi,Julie R. Brahmer,Scott N. Gettinger,David Smith,David F. McDermott,John D. Powderly,Richard D. Carvajal,Jeffrey A. Sosman,Michael B. Atkins,Philip D. Leming,David R. Spigel,Scott J. Antonia,Leora Horn,Charles G. Drake,Drew M. Pardoll,Lieping Chen,William H. Sharfman,Robert A. Anders,Janis M. Taube,Tracee L. McMiller,Haiying Xu,Alan J. Korman,Maria Jure-Kunkel,Shruti Agrawal,Dan McDonald,Georgia Kollia,Ashok Kumar Gupta,Jon M. Wigginton,Mario Sznol +29 more
TL;DR: Anti-PD-1 antibody produced objective responses in approximately one in four to one in five patients with non-small-cell lung cancer, melanoma, or renal-cell cancer; the adverse-event profile does not appear to preclude its use.
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The blockade of immune checkpoints in cancer immunotherapy
TL;DR: Preliminary clinical findings with blockers of additional immune-checkpoint proteins, such as programmed cell death protein 1 (PD1), indicate broad and diverse opportunities to enhance antitumour immunity with the potential to produce durable clinical responses.
Journal ArticleDOI
Mutations of the BRAF gene in human cancer
Helen Davies,Graham R. Bignell,Charles Cox,Philip J. Stephens,Sarah Edkins,S. M. Clegg,Jon W. Teague,Hayley Woffendin,Mathew J. Garnett,William Bottomley,Neil Davis,Ed Dicks,Rebecca Ewing,Yvonne Floyd,Kristian Gray,S. Hall,Rachel Hawes,Jaime Hughes,Vivian Kosmidou,Andrew Menzies,Catherine Mould,Adrian Parker,Claire Stevens,Stephen Watt,Steven Hooper,Rebecca Wilson,Hiran Jayatilake,Barry A. Gusterson,Colin Cooper,Janet Shipley,Darren Hargrave,Kathy Pritchard-Jones,Norman J. Maitland,Georgia Chenevix-Trench,Gregory J. Riggins,Darell D. Bigner,Giuseppe Palmieri,Antonio Cossu,Adrienne M. Flanagan,Andrew G. Nicholson,Judy W. C. Ho,Suet Yi Leung,Siu Tsan Yuen,Barbara L. Weber,Hilliard F. Seigler,Timothy L. Darrow,Hugh Paterson,Richard Marais,Christopher J. Marshall,Richard Wooster,Michael R. Stratton,P. Andrew Futreal +51 more
TL;DR: BRAF somatic missense mutations in 66% of malignant melanomas and at lower frequency in a wide range of human cancers, with a single substitution (V599E) accounting for 80%.
Journal ArticleDOI
Signatures of mutational processes in human cancer
Ludmil B. Alexandrov,Serena Nik-Zainal,Serena Nik-Zainal,David C. Wedge,Samuel Aparicio,Sam Behjati,Sam Behjati,Andrew V. Biankin,Graham R. Bignell,Niccolo Bolli,Niccolo Bolli,Åke Borg,Anne Lise Børresen-Dale,Anne Lise Børresen-Dale,Sandrine Boyault,Birgit Burkhardt,Adam Butler,Carlos Caldas,Helen Davies,Christine Desmedt,Roland Eils,Jorunn E. Eyfjord,John A. Foekens,Mel Greaves,Fumie Hosoda,Barbara Hutter,Tomislav Ilicic,Sandrine Imbeaud,Sandrine Imbeaud,Marcin Imielinsk,Natalie Jäger,David T. W. Jones,David T. Jones,Stian Knappskog,Stian Knappskog,Marcel Kool,Sunil R. Lakhani,Carlos López-Otín,Sancha Martin,Nikhil C. Munshi,Nikhil C. Munshi,Hiromi Nakamura,Paul A. Northcott,Marina Pajic,Elli Papaemmanuil,Angelo Paradiso,John V. Pearson,Xose S. Puente,Keiran Raine,Manasa Ramakrishna,Andrea L. Richardson,Andrea L. Richardson,Julia Richter,Philip Rosenstiel,Matthias Schlesner,Ton N. Schumacher,Paul N. Span,Jon W. Teague,Yasushi Totoki,Andrew Tutt,Rafael Valdés-Mas,Marit M. van Buuren,Laura van ’t Veer,Anne Vincent-Salomon,Nicola Waddell,Lucy R. Yates,Icgc PedBrain,Jessica Zucman-Rossi,Jessica Zucman-Rossi,P. Andrew Futreal,Ultan McDermott,Peter Lichter,Matthew Meyerson,Matthew Meyerson,Sean M. Grimmond,Reiner Siebert,Elias Campo,Tatsuhiro Shibata,Stefan M. Pfister,Stefan M. Pfister,Peter J. Campbell,Peter J. Campbell,Peter J. Campbell,Michael R. Stratton,Michael R. Stratton +84 more
TL;DR: It is shown that hypermutation localized to small genomic regions, ‘kataegis’, is found in many cancer types, and this results reveal the diversity of mutational processes underlying the development of cancer.
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