Journal ArticleDOI
The immunology of acute stroke.
Ángel Chamorro,Andreas Meisel,Anna M. Planas,Xabier Urra,Diederik van de Beek,Roland Veltkamp +5 more
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TLDR
The multifaceted role of the immune system in the pathophysiology of acute stroke is discussed, with increased incidence of infections observed after acute stroke, and might result from activation of long-distance feedback loops between the CNS and peripheral immune organs.Abstract:
Recent clinical and experimental studies have highlighted a complex role for the immune system in the pathophysiological changes that occur after acute stroke. Sensors of the innate immune system such as Toll-like receptors, or effectors such as the lectin pathway of complement activation and innate immune cells, are activated by brain ischaemia and tissue damage, leading to amplification of the inflammatory cascade. Activation of the adaptive arm of the immune system, mediated by lymphocyte populations including T and B cells, regulatory T cells, and γδT cells, in response to stroke can lead to deleterious antigen-specific autoreactive responses but can also have cytoprotective effects. Increased incidence of infections is observed after acute stroke, and might result from activation of long-distance feedback loops between the CNS and peripheral immune organs, which are thought to play a part in stroke-induced immunodepression. Ongoing clinical trials are investigating whether the preventive use of antibiotics improves functional outcome after stroke. This Review discusses the multifaceted role of the immune system in the pathophysiology of acute stroke.read more
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Association of Blood Biomarkers of Inflammation With Penumbra Consumption After Mechanical Thrombectomy in Patients With Acute Ischemic Stroke
Laura Mechtouff,Noëlie Debs,Carole Frindel,Alexandre Bani-Sadr,Thomas Bochaton,Alexandre Paccalet,Claire Crola Da Silva,Marie-Andrée Buisson,Camille Amaz,Yves Berthezène,Omer Eker,Morgane Bouin,Charles de Bourguignon,Nathan Mewton,Michel Ovize,Gabriel Bidaux,Norbert Nighoghossian,Tae-Hee Cho +17 more
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DissertationDOI
Lokalisierung und Charakterisierung Foxp3+ regulatorischer T-Zellen bis zu 30 Tage nach mechanischer und ischämischer Läsion des Gehirns
TL;DR: This study sought to analyse the temporal distribution, location, induction and effect of Tregs on days 7, 14 and 30 following entorhinale cortex lesion (ECL) and cerebral infarction in mice after transient middle cerebral artery occlusion (MCAO).
Journal ArticleDOI
Advancements in Hydrogel Application for Ischemic Stroke Therapy
TL;DR: In this article , the authors discuss the pathophysiology of stroke and the development of injectable hydrogels in the application of both stroke treatment and neural tissue engineering, and discuss the prospect and the challenges of hydrogel-based strategies in the treatment of ischemic strokes.
Journal ArticleDOI
Iron, ferroptosis, and ischemic stroke
TL;DR: In this paper , a review summarizes the current understanding of pathological events associated with iron in ischemic stroke and discusses relevant drug development, and discusses the relevant drug developments. But, the precise molecular mechanism of neuronal damage during ischemia remains unclear; therefore, the effective treatment of post-ischemic stroke remains a critical challenge.
References
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Journal ArticleDOI
Pattern Recognition Receptors and Inflammation
Osamu Takeuchi,Shizuo Akira +1 more
TL;DR: The role of PRRs, their signaling pathways, and how they control inflammatory responses are discussed.
Journal ArticleDOI
Regulatory T Cells and Immune Tolerance
TL;DR: The cellular and molecular basis of Treg development and function is revealed and dysregulation of T Regs in immunological disease is implicates.
Journal ArticleDOI
Microglia: active sensor and versatile effector cells in the normal and pathologic brain
TL;DR: This review focuses on several key observations that illustrate the multi-faceted activities of microglia in the normal and pathologic brain.
Journal ArticleDOI
Development of Monocytes, Macrophages, and Dendritic Cells
TL;DR: The current understanding of myeloid lineage development is reviewed and the developmental pathways and cues that drive differentiation are described, which are central to the development of immunologic memory and tolerance in mice.
Journal ArticleDOI
Sterile inflammation: sensing and reacting to damage
Grace Y. Chen,Gabriel Núñez +1 more
TL;DR: The triggers and receptor pathways that result in sterile inflammation and its impact on human health are reviewed.