Journal ArticleDOI
The implication of long non-coding RNAs in the diagnosis, pathogenesis and drug resistance of pancreatic ductal adenocarcinoma and their possible therapeutic potential.
TLDR
The current review discusses the potential role and molecular mechanism of lncRNA in regulating the prominent hallmarks of cancer including abnormal growth, survival, metastasis, and drug-resistance in PDAC and highlights the possible application of various therapeutic strategies.About:
This article is published in Biochimica et Biophysica Acta.The article was published on 2020-12-01. It has received 108 citations till now. The article focuses on the topics: Cellular homeostasis.read more
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Regulation of Nuclear Factor-KappaB (NF-κB) signaling pathway by non-coding RNAs in cancer: Inhibiting or promoting carcinogenesis?
Sepideh Mirzaei,Ali Zarrabi,Farid Hashemi,Amirhossein Zabolian,Hossein Saleki,Adnan Ranjbar,Seyed Hesam Seyed Saleh,Morteza Bagherian,Seyed Omid Sharifzadeh,Kiavash Hushmandi,Alena Liskova,Peter Kubatka,Pooyan Makvandi,Vinay Tergaonkar,Alan Prem Kumar,Milad Ashrafizadeh,Gautam Sethi +16 more
TL;DR: In this paper, it has been shown that microRNAs (miRNAs) can dually inhibit/induce NF-κB signaling thereby affecting the growth and migration of cancer cells.
Journal ArticleDOI
Long non-coding RNAs in the doxorubicin resistance of cancer cells.
Saeed Ashrafizaveh,Milad Ashrafizadeh,Ali Zarrabi,Kiavash Husmandi,Amirhossein Zabolian,Shahinozzaman,Amir Reza Aref,Michael R. Hamblin,Noushin Nabavi,Francesco Crea,Yuzhuo Wang,Kwang Seok Ahn +11 more
Journal ArticleDOI
Emerging role of exosomes in cancer progression and tumor microenvironment remodeling
Mahshid Deldar Abad Paskeh,Maliheh Entezari,Sepideh Mirzaei,Amirhossein Zabolian,Hossein Saleki,Mohamad Javad Naghdi,Sina J. Sabet,M. Khoshbakht,M. Hashemi,Kiavash Hushmandi,Gautam Sethi,Ali Zarrabi,Alan Prem Kumar,Shing Cheng Tan,N. Papadakis,Athanasios Alexiou,Md. Asiful Islam,Ebrahim Mostafavi,Milad Ashrafizadeh +18 more
TL;DR: The role of exosomes in cancer progression and therapy is discussed in this article , where the authors provide a comprehensive understanding of the role of the exosome in cancer therapy, focusing on their therapeutic value in cancer progress and remodeling of the tumor microenvironment.
Journal ArticleDOI
The pleiotropic role of transcription factor STAT3 in oncogenesis and its targeting through natural products for cancer prevention and therapy.
Manoj Garg,Muthu K. Shanmugam,Vipul Bhardwaj,Akul Goel,Rajat Gupta,Arundhiti Sharma,Prakash Baligar,Alan Prem Kumar,Boon Cher Goh,Boon Cher Goh,Lingzhi Wang,Gautam Sethi +11 more
TL;DR: This review has discussed the classical regulation of STAT3 via diverse growth factors, cytokines, G‐protein‐coupled receptors, as well as toll‐like receptors, and the potential role of noncoding RNAs in regulating STAT3 signaling.
Journal ArticleDOI
The long and short non-coding RNAs modulating EZH2 signaling in cancer
Sepideh Mirzaei,Mohammad Hossein Gholami,Kiavash Hushmandi,Farid Hashemi,Amirhossein Zabolian,Israel Cañadas,Ali Zarrabi,Noushin Nabavi,Amir Reza Aref,Francesco Crea,Yuzhuo Wang,Milad Ashrafizadeh,Alan Prem Kumar +12 more
TL;DR: In this paper , a mechanistic discussion of ncRNAs role in regulating EZH2 expression in different cancers is provided, with a focus on molecular pathways leading to clinical translation.
References
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TL;DR: The results of an international collaboration to produce and make freely available a draft sequence of the human genome are reported and an initial analysis is presented, describing some of the insights that can be gleaned from the sequence.
Journal ArticleDOI
Cancer statistics, 2019.
TL;DR: The overall cancer death rate dropped continuously from 1991 to 2016 by a total of 27%, translating into approximately 2,629,200 fewer cancer deaths than would have been expected if death rates had remained at their peak.
Journal ArticleDOI
Cancer statistics in China, 2015
Wanqing Chen,Rongshou Zheng,Peter D. Baade,Siwei Zhang,Hongmei Zeng,Freddie Bray,Ahmedin Jemal,Xue Qin Yu,Jie He +8 more
TL;DR: Many of the estimated cancer cases and deaths can be prevented through reducing the prevalence of risk factors, while increasing the effectiveness of clinical care delivery, particularly for those living in rural areas and in disadvantaged populations.
Journal ArticleDOI
Genome Regulation by Long Noncoding RNAs
John L. Rinn,Howard Y. Chang +1 more
TL;DR: Long noncoding RNAs (lncRNAs) as discussed by the authors form extensive networks of ribonucleoprotein (RNP) complexes with numerous chromatin regulators and then target these enzymatic activities to appropriate locations in the genome.