Tumor and its microenvironment: A synergistic interplay
Veronica Catalano,Alice Turdo,Simone Di Franco,Francesco Dieli,Matilde Todaro,Giorgio Stassi +5 more
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TLDR
The synergistic effect of hypoxia inducible factors (HIFs) and vascular endothelial growth factors (VEGFs) in the successful outgrowth of metastasis is focused on, integrating therefore many of the emerging models and theories in the field.About:
This article is published in Seminars in Cancer Biology.The article was published on 2013-12-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Tumor microenvironment & Tumor progression.read more
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Antiproliferative activity of di-2-pyridylhydrazone dithiocarbamate acetate partly involved in p53 mediated apoptosis and autophagy.
TL;DR: DpdtaA could upregulate p53 via down-regulating the Mdm2, accordingly leading to changes of bcl family proteins, indicating that a p53-dependent intrinsic apoptosis was partly involved and the alternations in lysosome membrane permeability and acidic vacuoles as well as LC3-II upregulation indicated that autophagy was involved.
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Inhibitory effects of dieckol on hypoxia-induced epithelial-mesenchymal transition of HT29 human colorectal cancer cells
TL;DR: It is suggested that dieckol may inhibit hypoxia-induced EMT in HT29 cells by regulating the levels of cellular ROS and protein expression levels downstream of the HIF1α signaling pathway, and has the potential to become an attractive therapeutic agent for the treatment of colorectal cancer.
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Salvianolic acid A inhibits tumor-associated angiogenesis by blocking GRP78 secretion
TL;DR: SAA has the novel function of anti-angiogenesis via the tumor environment and can facilitate GRP78 of cytosol sorted into lysosome for degradation rather than exosome.
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Epithelial-mesenchymal transition and metastasis of colon cancer cells induced by the FAK pathway in cancer-associated fibroblasts.
Xuefeng Xuefeng,Ming-Xing Hou,Zhi-Wen Yang,Agudamu Agudamu,Feng Wang,Xiu-Lan Su,Xian Li,Lin Shi,Terigele Terigele,Li-Li Bao,Xin-Lin Wu +10 more
TL;DR: CAFs stimulate EMT in human colon cancer LOVO cells by secreting LOXL2 to activate the FAK signaling pathway, thereby promoting tumor metastasis and reducing the invasion and metastasis of colon cancer cells.
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Therapeutic effect of a TM4SF5-specific monoclonal antibody against colon cancer in a mouse model
Young-Eun Kim,Sanghoon Kwon,Guang Wu,Dongbum Kim,Byoung Kwon Park,Jeong-A Park,Kyung-Chan Choi,Doo-Sik Kim,Hyung-Joo Kwon,Younghee Lee +9 more
TL;DR: It is suggested that the TM4SF5-specific monoclonal antibody has a therapeutic effect against colon cancer.
References
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Global cancer statistics
TL;DR: A substantial proportion of the worldwide burden of cancer could be prevented through the application of existing cancer control knowledge and by implementing programs for tobacco control, vaccination, and early detection and treatment, as well as public health campaigns promoting physical activity and a healthier dietary intake.
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A genetic model for colorectal tumorigenesis
Eric R. Fearon,Bert Vogelstein +1 more
TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
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Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
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Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
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Epithelial-Mesenchymal Transitions in Development and Disease
Jean Paul Thiery,Jean Paul Thiery,Hervé Acloque,Ruby Yun-Ju Huang,Ruby Yun-Ju Huang,M. Angela Nieto +5 more
TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.