Tumor and its microenvironment: A synergistic interplay
Veronica Catalano,Alice Turdo,Simone Di Franco,Francesco Dieli,Matilde Todaro,Giorgio Stassi +5 more
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TLDR
The synergistic effect of hypoxia inducible factors (HIFs) and vascular endothelial growth factors (VEGFs) in the successful outgrowth of metastasis is focused on, integrating therefore many of the emerging models and theories in the field.About:
This article is published in Seminars in Cancer Biology.The article was published on 2013-12-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Tumor microenvironment & Tumor progression.read more
Citations
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Cancer-Associated Fibroblasts: The Origin, Biological Characteristics and Role in Cancer—A Glance on Colorectal Cancer
Charalampos Fotsitzoudis,Asimina Koulouridi,Ippokratis Messaritakis,Theocharis Konstantinidis,Nikolaos Gouvas,John Tsiaoussis,John Souglakos +6 more
TL;DR: Tumor microenvironment is a major contributor to tumor growth, metastasis and resistance to therapy, which consists of many cancer-associated fibroblasts (CAFs), which derive from different types of cells.
Journal ArticleDOI
Higher Ki67 expression in fibroblast like cells at invasive front indicates better clinical outcomes in oral squamous cell carcinoma patients.
Yue Jing,Yan Yang,Fengyao Hao,Yuxian Song,Xiaoxin Zhang,Ye Zhang,Xiaofeng Huang,Qingang Hu,Yanhong Ni +8 more
TL;DR: It is shown that higher Ki67 expression in FLCs at IF indicated better clinical outcomes for OSCC patients and Cox multivariate analysis revealed that Ki67expression in F LCs atIF could not be an independent prognostic factor for OS CC patients.
Journal ArticleDOI
Transdifferentiation of type II alveolar epithelial cells induces reactivation of dormant tumor cells by enhancing TGF-β1/SNAI2 signaling.
Yuanhong Zhou,Qiang Liu,Xiangchen Dai,Yuling Yan,Ying Yang,Hua Li,Xiaoling Zhou,Wenqi Gao,Xiaolan Li,Zuyang Xi +9 more
TL;DR: It is demonstrated that tumor cells may promote AEC II transdifferentiation, which may induce the reactivation of 3D-established DTCs by promoting TGF-β1/SNAI2 signaling and provide novel therapeutic strategies for the inhibition of the dormant-to-proliferating switch.
Dissertation
Novel role of lymphatic and blood vasculatures in breast cancer growth and metastasis and peptide agents with anti-lymphangiogenic and anti-angiogenic activity
TL;DR: This book presents a meta-anatomy of the determinants of infectious disease and some of the immune responses to these diseases have been described in detail.
Journal ArticleDOI
Impact of a Desmoplastic Tumor Microenvironment for Colon Cancer Drug Sensitivity: A Study with 3D Chimeric Tumor Spheroids.
Venkanagouda S. Goudar,Manohar Prasad Koduri,Manohar Prasad Koduri,Yen Nhi Ngoc Ta,Yunching Chen,Li An Chu,Long Sheng Lu,Fan-Gang Tseng +7 more
TL;DR: In this paper, the authors developed an in vitro 3D co-culture model in a microwell 3D (μ-well 3D) cell-culture array platform to mimic the tumor microenvironment (TME).
References
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A genetic model for colorectal tumorigenesis
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TL;DR: A model for the genetic basis of colorectal neoplasia that includes the following salient features is presented, which may be applicable to other common epithelial neoplasms, in which tumors of varying stage are more difficult to study.
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Tumor Angiogenesis: Therapeutic Implications
TL;DR: This new capillary growth is even more vigorous and continuous than a similar outgrowth of capillary sprouts observed in 2016 and is likely to be accompanied by neovascularization.
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Immunity, Inflammation, and Cancer
TL;DR: The principal mechanisms that govern the effects of inflammation and immunity on tumor development are outlined and attractive new targets for cancer therapy and prevention are discussed.
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TL;DR: The mesenchymal state is associated with the capacity of cells to migrate to distant organs and maintain stemness, allowing their subsequent differentiation into multiple cell types during development and the initiation of metastasis.