Tumor and its microenvironment: A synergistic interplay
Veronica Catalano,Alice Turdo,Simone Di Franco,Francesco Dieli,Matilde Todaro,Giorgio Stassi +5 more
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TLDR
The synergistic effect of hypoxia inducible factors (HIFs) and vascular endothelial growth factors (VEGFs) in the successful outgrowth of metastasis is focused on, integrating therefore many of the emerging models and theories in the field.About:
This article is published in Seminars in Cancer Biology.The article was published on 2013-12-01 and is currently open access. It has received 343 citations till now. The article focuses on the topics: Tumor microenvironment & Tumor progression.read more
Citations
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Targeting Tumor Microenvironment for Cancer Therapy.
TL;DR: In this article, a big effort has been made to develop new therapeutic strategies towards a more efficient targeting of tumor microenvironment (TME) components, extending from conventional therapeutics, to combined therapies and nanomedicines; and the development of models that accurately resemble the TME for bench investigations.
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GSH‐Depleted PtCu3 Nanocages for Chemodynamic‐ Enhanced Sonodynamic Cancer Therapy
Xiaoyan Zhong,Xianwen Wang,Liang Cheng,Yong'an Tang,Guiting Zhan,Fei Gong,Rui Zhang,Jun Hu,Zhuang Liu,Xiangliang Yang +9 more
TL;DR: PtCu3 nanocages are first reported as acting as a sonosensitizer with highly efficient ROS generation under ultrasound irradiation, and can act as horseradish peroxidase‐like nanozymes, catalyzing the decomposition of H2O2 into •OH under acidic conditions for CDT.
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Exosome in tumour microenvironment: overview of the crosstalk between normal and cancer cells.
TL;DR: Since the finding that exosomes content resembles that of the cell of origin, they may be regarded as suitable biomarkers for cancer diagnosis, allowing for diagnosis and prognosis via a minimal invasive procedure.
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Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies
TL;DR: Many anticancer polyphenols cause cellular growth arrest through the induction of a ROS-dependent premature senescence and are considered promising antitumour therapeutic tools.
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High-Performance Self-Cascade Pyrite Nanozymes for Apoptosis–Ferroptosis Synergistic Tumor Therapy
Xiangqin Meng,Dandan Li,Lei Chen,Lei Chen,Helen He,Qian Wang,Chaoyi Hong,Jiuyang He,Xingfa Gao,Yili Yang,Bing Jiang,Guohui Nie,Xiyun Yan,Xiyun Yan,Lizeng Gao,Lizeng Gao,Kelong Fan,Kelong Fan +17 more
TL;DR: In this paper, a pyrite peroxidase nanozyme with ultrahigh H2O2 affinity was presented, which achieved a 4144-and 3086-fold increase of catalytic activity compared with that of classical Fe3O4 nanozyme and natural horseradish peroxideidase, respectively.
References
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Hypoxia and RAS-signaling pathways converge on, and cooperatively downregulate, the RECK tumor-suppressor protein through microRNAs
Fabricio Loayza-Puch,Yasuko Yoshida,Tomoko Matsuzaki,Chiaki Takahashi,Hitoshi Kitayama,Makoto Noda +5 more
TL;DR: Data indicate that the hypoxia- and RAS-signaling pathways converge on RECK through miRNAs, cooperatively downregulating this tumor suppressor and thereby promoting malignant cell behavior.
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Small GTPase R-Ras Regulates Integrity and Functionality of Tumor Blood Vessels
Junko Sawada,Takeo Urakami,Fangfei Li,Akane Urakami,Weiquan Zhu,Minoru Fukuda,Dean Y. Li,Erkki Ruoslahti,Erkki Ruoslahti,Masanobu Komatsu +9 more
TL;DR: It is shown that R-Ras, a small GTPase of the Ras family, is essential for the establishment of mature, functional blood vessels in tumors and promotes normalization of the tumor vasculature.
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Delivery of CD44 shRNA/Nanoparticles within Cancer Cells: PERTURBATION OF HYALURONAN/CD44v6 INTERACTIONS AND REDUCTION IN ADENOMA GROWTH IN Apc Min/+ MICE
TL;DR: In vitro and in vivo, targeted inhibition of the expression of CD44v6 depletes the ability of the colon tumor cells to signal through hyaluronan-CD 44v6 interactions, providing insight into the novel therapeutic strategies of short hairpin RNA/nanoparticle technology and its potential for silencing genes associated with colon tumor Cells.
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High frequency of K-ras mutations in sporadic colorectal adenomas.
TL;DR: It was found that adenomas from patients with a personal history of colorectal cancer were more likely to contain a K-ras mutation than those from patients without such history, suggesting a possible difference in the molecular genesis of FAP and non-FAPAdenomas.
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Molecular Pathways: Involving Microenvironment Damage Responses in Cancer Therapy Resistance
Yu Sun,Peter S. Nelson +1 more
TL;DR: Emerging data indicating that genotoxic cancer treatments activate highly conserved damage response programs in benign constituents of the tumor microenvironment are described, which generate a proangiogenic, proinflammatory microenvironment.